â  the adverse effects of non-steroidal anti-inflammatory drugs (nsaids) on the upper gastrointestinal (gi) tract and small intestine are well established. the effect of such therapy on the large intestine, so called nsaid-induced colopathy, is less well described. nsaid-induced colopathy usually involves the right colon due to a higher concentration of the drug at this site, but the rectum may...

upper gastrointestinal bleeding (ugib) is defi ned as bleeding that results from lesions located above the ligament of treitz and is a common cause for emergency hospital admissions in patients with gastrointestinal disorders. ugib also increases the risk of morbidity and mortality in patients already hospitalized for other reasons. according to epidemiological surveys of acute ugib in iran, pe...

OBJECTIVE To review the management of acute gastrointestinal bleeding in the critically ill patient in a two part presentation. DATA SOURCES Articles and a review of studies reported from 1991 to 2001 and identified through a MEDLINE search of the English language literature on acute gastrointestinal bleeding. SUMMARY OF REVIEW Gastrointestinal bleeding is a relatively frequent problem in t...

BACKGROUND Despite the scanty data, proton pump inhibitors (PPI) are widely used for stress-related mucosal disease (SRMD) prophylaxis. There were few studies using PPI for SRMD prophylaxis but the results were conflicting, most probably due to inadequate sample size. The present meta-analysis aimed to determine the efficacy of PPI, as compared to histamine-2 receptor antagonists (H2RA) in the ...

Substantial evidence from randomized trials confirms benefit from aspirin in the secondary reduction of vascular disease but there is debate about its use in primary prevention. More recently, evidence from long-term follow up and other studies indicates a reduction in cancer by aspirin. The undesirable effects of aspirin include gastrointestinal bleeding and, rarely, cerebral bleeding. However...

Gastrointestinal bleeding related to portal hypertension is a serious complication in patients with liver cirrhosis. Most patients bleed from esophageal or gastric varices, but bleeding from ectopic varices or portal hypertensive gastropathy is also possible. The management of acute bleeding has changed over the last years. Patients are managed with a combination of endoscopic and pharmacologic...

Von Willebrand disease (VWD) is a bleeding disorder, resulting from quantitative or qualitative defect in von factor (VWF). A regulatory role for VWF angiogenesis was postulated upon the clinical observation that defects are associated with frequent occurrence of neoangiogenesis, particularly gastrointestinal (GI) tract. Vascular malformations GI tract cause digestive form either acute chronic ...

An evidence-based-medicine approach may be applied to studies in the medical literature to help physicians make sound judgments about efficacy and safety data and to improve clinical decision making. To assess the role of gastric acid suppression in the prevention of stress ulcer bleeding and in the management of upper gastrointestinal bleeding after successful hemostasis of bleeding peptic ulc...