Patients with gastroesophageal reflux disease may have disturbances of gastric motility, which could play a role in the pathophysiology of the disease. Recent studies have suggested that the gastric region just below the gastroesophageal junction may have a distinct physiological behavior. We determined whether patients with gastroesophageal reflux disease have abnormal residence of food in the...

BACKGROUND/AIMS Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve gastroesophageal reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and gastroesophageal reflux. METHODS The subjects were 10 normal ...

Background Gastroesophageal pathologies are common and multifactorial in patients with type 1 diabetes (T1DM). The evaluation with endoscopy and 24 h pH esophageal monitoring is expensive and not always available in all medical centers, especially in developing countries so more cost-effective algorithms for diagnosis are required. Clinical questionnaires are easy to apply but its utility for g...

A 4-month-old, intact male domestic short-hair cat was presented to Veterinary Hospital with an acuteonset of regurgitation and respiratory distress. Thoracic and abdominal radiographs identified a massconsisted of a heterogeneous mixture of soft tissue and gas densities between heart and craniodorsal part of the diaphragm that was shifted to the left. The stomach could not be seen clearly. Rad...

Simultaneous squamous cell carcinoma (SCC) of esophagus and gastroesophageal adenocarcinoma has rarely been reported. It is often difficult to diagnose this coexistence preoperatively due to the presence of esophageal stenosis. Herein, we report a patient with esophageal SCC whose gastroesophageal adenocarcinoma was also detected after pathologic examination of the resected specimen.

background epidemiology of diseases changes over time with changes in socio-economic status, culture and health care systems. gastroesophageal reflux disease (gerd) and peptic ulcer disease (pud) are among the diseases whose epidemiology has changed over the past few decades in the west. studies addressing the trend of gerd and pud occurrence in iran are lacking. we aimed to look at the time tr...

There has been controversy regarding the relationship between gastroesophageal reflux, microaspiration, and idiopathic pulmonary fibrosis (IPF). In the last decade, there is increasing evidence supporting a relationship between gastroesophageal reflux, microaspiration, and IPF. The presence of hiatal hernia further propagates microaspirations. Surgical management of hiatal hernia plays a vital ...

Gastroesophageal reflux is a very common disease. Almost everybody experiences heartburn from time to time but with different degree of severity. How does reflux occur, and which factors encourage or work against reflux is a very controversial matter. This article covers all controversial issues about the pathophysiology of gastroesophageal reflux and discusses the old and recent understanding ...

At the gastroesophageal junction, most vertebrates possess a functional lower esophageal sphincter (LES) which may serve to regulate the passage of liquids and food into the stomach and prevent the reflux of gastric contents into the esophagus. Snakes seemingly lack an LES and consume meals large enough to extend anteriorly from the stomach into the esophagus thereby providing the opportunity f...