Hydrogen sulfide is an endogenous mediator that relaxes vascular smooth muscle, exhibits several antiinflammatory activities, and contributes to gastric mucosal defense. This study was performed to examine the role of hydrogen sulfide in the resolution of injury; specifically, the healing of gastric ulcers. Ulcers were induced in rats by serosal application of acetic acid. This elicited a marke...

AIM Determination of the incidence of gastric ulcers in pigs slaughtered at Base Abattoir in Rwanda. MATERIALS AND METHODS Stomachs from all 5040 pigs that were slaughtered at Base Abattoir in Rwanda from August 2012 to August 2015 were examined for the presence and location of gastric ulcers. The results of the inspections were recorded and analyzed. Statistical analysis for Chi-square value...

The gastric ulcerogenic effect of the glucocorticoid, prednisolone, was studied in albino rats. Shay operation in forestomachectomized rats with intact adrenals induced acute gastric ulcers in the corpus, whereas adrenalectomy prevented the development of gastric ulcers in another group of forestomachectomized Shay rats. Only superficial erosion of gastric epithelium was noticed in 66.67% of th...

Oxidative stress is believed to initiate and aggravate many diseases including peptic ulcers and gastric carcinoma. We observed an increase in rat gastric mucosal lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in cold restraint stress-induced gastric ulceration while, in clinical peptic ulceration and gastric carcinoma patients, an increase in se...

Laparoscopic fundoplication has become the standard surgical procedure for the treatment of gastroesophageal reflux diseases such as reflux esophagitis and hiatal hernia (1). Long-term complications of fundoplication include prolonged dysphagia, increased flatulence, gas-bloat syndrome, and gastric ulcers (GU). Of these complications, GU occurs in nearly 1-5% of the patients (2). These ulcers o...

Since William Beaumont's classic description of gastric physiology in 1847, the focus of clinical practice and basic research concerning gastric and duodenal ulcers has centered on the secretion of acid and pepsin. In addition to these well-known factors (largely determined by heredity, age, and oral intake), the search for other agents that alter the mucosal barrier has identified a bacillus, ...

presentedwithepigastralgiaandtransientsubsternaldiscomfortjustafterswaIlowingfood, In this patient, endoscopic examination revealed multiple esophageal ulceration and kissingtype gastric ulceration. The esophageal ulcers were not improved by frequent antacid therap7 for six weeks, while gastric ulcers responded we]1 to the therapl. Steroid therapy was begun and esophagoscopy revealed scarred ul...

Gastric involvement is the least frequent manifestation of Behçet's disease, and effective treatment for it unknown. Here the case of a patient with gastric involvement in Behçet's disease that was markedly improved with adalimumab therapy is presented. A 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. Behçet's disease was suspected; then, prednisolone and colch...

Twenty-five patients with healed gastric ulcers completed an 11-month double-blind controlled trial comparing cimetidine 1 g daily with placebo in the prevention of ulcer relapse. Ulcers recurred in 14 patients, 12 on placebo, 2 on cimetidine. In 11 patients, 9 on cimetidine, 2 on placebo, the ulcers remained healed at the end of the trial (P less than 0.002). Cimetidine 1 g daily significantly...

Invasive gastric mucormycosis is a rare and fatal disease. We report a rare case with longstanding SLE who presented with fever. Autopsy showed multiple small shallow-based ulcers in the antrum. Histologic examination showed invasive mucormycosis. This is a rare case of invasive gastric mucormycosis localized exelusively in the stomach.