BACKGROUND AND AIMS The success of Helicobacter pylori eradication regimens depends on gastric pH, inflammation, and mucus thickness. Our aim was to investigate the effects of acid secretion, inflammation, and mucolysis on gastric antibiotic transfer. SUBJECTS AND METHODS A total of 134 anaesthetised rats were given metronidazole, amoxicillin, or clarithromycin intravenously and gastric conte...

BACKGROUND Ethno-botanical information shows that Eremomastax speciosa is used in the traditional management of various stomach complaints including gastro-duodenal ulcers. MATERIALS AND METHODS In this study, we tested the cytoprotective potential of the whole plant methanol extract (100-200 mg/kg, p.o), against HCl/ethanol, absolute ethanol, cold/restraint stress rats, and pylorus legated r...

Transforming growth factor alpha (TGF alpha) is thought to participate in the normal and pathologic processes of numerous tissues, including the gastric mucosa. To explore its role in vivo, transgenic mice were generated overexpressing TGF alpha in the stomach. TGF alpha induced dramatic structural and functional lesions of the glandular stomach that were similar to Ménétrier's disease in human...

Teaching gastrointestinal physiology to preclinical medical students presents problems in finding suitable practical exercises to demonstrate the physiology of gastric acid secretion. In our course, students measure their own gastric secretory activity by the use of nasogastric tubes. Gastric secretion can be stimulated by insulin-induced hypoglycemia or by pentagastrin, a synthetic gastrin ana...

RATIONALE Underinflation of the tracheal cuff frequently occurs in critically ill patients and represents a risk factor for microaspiration of contaminated oropharyngeal secretions and gastric contents that plays a major role in the pathogenesis of ventilator-associated pneumonia (VAP). OBJECTIVES To determine the impact of continuous control of tracheal cuff pressure (P(cuff)) on microaspira...

A case of right sided pulmonary hypoplasia with tuberculosis is described . A 7 months male was admitted in our department with complaints of recurrent chest infections since birth. Clinical examination revealed smaller right hemithorax. Serial chest Xrays showed non progressive lesions over several months . Bronchoscopy and CT scan thorax confirmed the diagnosis of right sided pulmonary hypopl...

BACKGROUND Secretions contaminated with oral, nasal, and gastric bacteria accumulate in the subglottic space, above the endotracheal tube cuff. If these secretions are aspirated into lower airways, the intubated patient will be susceptible to ventilator-associated pneumonia (VAP). The aim of this study was to investigate the effect of inspiratory pause maneuver for intermittent subglottic secre...

Biological activity of bovine kappa-caseino glycomacropeptide (GMP) has received much attention in recent years. Research has focused on the ability of GMP to bind cholera and Escherichia coli enterotoxins, inhibit bacterial and viral adhesion, suppress gastric secretions, promote bifidobacterial growth and modulate immune system responses. Of these, protection against toxins, bacteria, and vir...

Pancreatic pseudocysts (PPs) are collections of pancreatic secretions that lined by fibrous tissues and may contain necrotic debris or blood. The interventions including percutaneous, endoscopic surgical approaches based on the size, location, symptoms complications a pseudocyst. With availability advanced imaging systems cameras, better hemostatic equipment’s excellent laparoscopic techniques,...