Aloe buettneri A. Berger is commonly used in traditional Togolese medicine to treat inflammatory and gastric ulcers. The present study examined the gastro-protection effect of the hydro-alcoholic extract of A. buettneri on mucus production and gastric pH. A gastric ulcer is induced by ethanol 95° alone (1 ml/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising L-NA...

abstract background: gastric cancer is one of the most common malignant tumors in iran. hypomethylation and/or hypermethylation of dna have been described in gastric cancer and is presumed to be an early event in this process. objective: we hypothesized that single nucleotide polymorphisms of dnmt1 gene may be associated with the genetic susceptibility to gastric cancer. methods: 200 patients a...

background: gastric cancer is the fifth most common cancer in the world and the third leading cause of death from cancer worldwide. this study aims to assess the epidemiology of gastric cancer in ardabil province, iran. methods: this was a descriptive cross-sectional study performed on 1056 patients with gastric cancer registered in the ardabil cancer registry. data were collected by a checklis...

background gastric cancer is the second leading cause of cancer-related deaths worldwide and it seems that environmental and lifestyle factors and infection with helicobacter pylori (h. pylori) have a major role in the etiology of gastric cancer. objectives the aim of this study was to investigate the presence of h. pylori dna in archival gastric tissues of patients with gastric cancer disease ...

hydrogen sulfide (h2s) has been shown to protect the gastric mucosa through several protective mechanisms but till now its effect on mrna expression of sodium bicarbonate cotransporter 1 (nbc1), trefoil factor1 (tff1) and trefoil factor2 (tff2) was not investigated. this study was aimed to evaluate the effect of h2s on mrna expression of nbc1, tff1 and tff2 in rat gastric mucosa in response to ...

background: chronic inflammation and dys-regulation of the immune system mechanisms are now well established as primary triggers of gastric cancer and peptic ulcer disease. galectin-9 (gal-9) is a member of the galectin family and known as an inducer of cell aggregation, adhesion and apoptosis. gal-9 interaction with its main ligand t-cell immunoglobulin and mucin domain protein-3 (tim-3) leads...

Hydrogen sulfide (H2S) has been shown to protect the gastric mucosa through several protective mechanisms but till now its effect on mRNA expression of sodium bicarbonate cotransporter 1 (NBC1), trefoil factor1 (TFF1) and trefoil factor2 (TFF2) was not investigated. This study was aimed to evaluate the effect of H2S on mRNA expression of NBC1, TFF1 and TFF2 in rat gastric ...

Background: Basic fibroblast growth factor (bFGF) is a glycoprotein with stimulating ability of angiogenesis. In addition, bFGF plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases was not reported. Therefore, we aimed to determine the bFGF levels in gastric u...