Nasal solutions of almotriptan malate were prepared in phosphate buffer containing different proportions of HPMC E15. In vitro permeation studies were performed using Franz diffusion cell with dialysis membrane and ex vivo permeation studies were carried out using sheep nasal mucosal layer. The formulations were radiolabeled with 99mTc and the nasal residence time was studied in rabbits. Nasal ...

Monoclonal antibodies Ost6 and Ost7 (mouse Immunoglobulin G1) to human osteogenic sarcoma were isolated from ascitic fluid and labeled with radioiodine. After injection into athymic nu/nu mice with s.c. xenografts of human osteogenic sarcoma, the uptake of radioactivity in tumors, visceral organs, and blood was determined. Five days after injection, Ost6 and Ost7 showed preferential accumulatio...

................................................................................................................... 1 SAMMANFATTNING ................................................................................................... 3 LIST OF PAPERS ........................................................................................................... 5 ABBREVIATIONS ..........................

A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these ...

Myocardial perfusion scintigraphy (MPS) is the only widely available method of direct assessment of myocardial perfusion. It involves intravenous injection of small amounts of a radioactive tracer at peak stress, followed by imaging of the heart with a gamma camera. There are three commercially available tracers: thallium-201 and two technetium-labelled tracers, sestamibi and tetrofosmin. All t...

Radioactive agents currently available for imaging infection by gamma scintigraphy do so by identifying inflammation in response to the infection, and are therefore non-specific in so far as they are unable to distinguish between infective and non-infective inflammation. The term ‘infection imaging’ is therefore generally synonymous with ‘inflammation imaging’. This article will briefly review ...

3 Abstract Marvola, J. 2008. Neutron Activation-based Gamma Scintigraphic Imaging and Scintigraphy-based Pharmacokinetic Modelling of Per Oral Controlled Release Drug Delivery Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki, 22/2008, xx pp., ISBN 978952-10-4684-1 (paperback), ISBN 978-952-10-4685-8 (PDF), ISSN 1795-7079 The per oral route of administration is th...

Canine myocardial infarcts resulting from ligation of the left anterior descending coronary artery were localized in vivo by gamma scintigraphy following the intravenous injection of l'I anticardiac myosin antibody (Fab')2. The anteroapical location of the image was confirmed by demonstration of the blood pool with "mTc sulfur colloid, and by subsequent imaging of the excised heart. The scintig...

In the present study, we formulated long circulating liposomes for amphotericin B and characterized them. The formulation was optimized using 2(3) factorial designs. Pegylated liposomal formulation showed favorable results with reference to particle size (247.33±9.60 nm), percent entrapment efficiency (94.55±3.34%). TEM studies revealed that the liposomes were essentially spherical, hollow, and...