نتایج جستجو برای: galectin 1

تعداد نتایج: 2755360  

Journal: :Journal of cell science 1998
J Y Choi A J van Wijnen F Aslam J D Leszyk J L Stein G S Stein J B Lian S Penman

The protein composition of the nuclear matrix changes significantly as the osteoblast matures from a proliferating pre-osteoblast to an osteocyte embedded in a mineralized matrix. These matrix protein are the result of developmental stage-specific gene expression during osteoblast differentiation. To isolate nuclear matrix proteins unique to the bone phenotype we analyzed nuclear matrix prepara...

Journal: :The Journal of biological chemistry 1998
J Kopitz C von Reitzenstein M Burchert M Cantz H J Gabius

Cell density-dependent inhibition of growth and neural differentiation in the human neuroblastoma cell line SK-N-MC are associated with a ganglioside sialidase-mediated increase of GM1 and lactosylceramide at the cell surface. Because these glycolipids expose galactose residues, we have initiated the study of the potential role of galectins in such cellular events. Using specific antibodies, ga...

Journal: :Annals of the rheumatic diseases 2004
M Guévremont J Martel-Pelletier C Boileau F-T Liu M Richard J-C Fernandes J-P Pelletier P Reboul

BACKGROUND Galectin-3 is a lectin detected in mature and early hypertrophic chondrocytes; osteoarthritic (OA) chondrocytes can re-express hypertrophic markers. OBJECTIVE To investigate the synthesis and subcellular localisation of galectin-3 in adult chondrocytes as well as the possibility of cleavage of galectin-3 by collagenase-1 and -3. METHODS Galectin-3 was assessed by immunohistochemi...

2016
Hyeok Gu Kang Da-Hyun Kim Seok-Jun Kim Yunhee Cho Junghyun Jung Wonhee Jang Kyung-Hee Chun

Ovarian cancer is the most lethal gynecologic disease because usually, it is lately sensed, easily acquires chemoresistance, and has a high recurrence rate. Recent studies suggest that ovarian cancer stem cells (CSCs) are involved in these malignancies. Here, we demonstrated that galectin-3 maintains ovarian CSCs by activating the Notch1 intracellular domain (NICD1). The number and size of ovar...

2016
Kuan-Ting Liu Yao-Hua Liu Yen-Hsu Chen Chun-Yu Lin Chung-Hao Huang Meng-Chi Yen Po-Lin Kuo

Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum con...

Journal: :Biochimica et biophysica acta 2012
Adriana Lepur Michael C Carlsson Ruđer Novak Jerka Dumić Ulf J Nilsson Hakon Leffler

BACKGROUND Galectin-3 (the Mac-2 antigen) is abundantly expressed in both macrophage like cells and certain non-macrophage cells. We have studied endocytosis of galectin-3 as one important step relevant for its function, and compared it between variants of a macrophage like cell line, and non-macrophage cells. METHODS Endocytosis of galectin-3 was observed by fluorescence microscopy and measu...

2014
Christoph-A von Klot Mario W Kramer Inga Peters Joerg Hennenlotter Mahmoud Abbas Ralph Scherer Thomas RW Herrmann Arnulf Stenzl Markus A Kuczyk Juergen Serth Axel S Merseburger

BACKGROUND Galectins are known to regulate cell differentiation and growth as well as cell adhesion and apoptosis. Galectins have been discussed as possible prognosticators for survival in renal cell cancer (RCC) and other urological tumors. They might also play an emerging role as possible new marker-proteins for RCC. In this study, we analyzed the expression of galectin-1 and galectin-3 mRNA ...

Journal: :Antimicrobial agents and chemotherapy 2012
Christian St-Pierre Michel Ouellet Denis Giguère Reiko Ohtake René Roy Sachiko Sato Michel J Tremblay

Despite significant improvements, antiretroviral therapies against HIV-1 are plagued by a high frequency of therapeutic failures that have been associated with acquisition of drug resistance. We recently reported that HIV-1 exploits a host glycan binding protein, galectin-1, to increase its attachment to host cells, thereby increasing its overall infectivity in susceptible cells. This finding s...

Journal: :Archives of otolaryngology--head & neck surgery 2003
Carine Delbrouck Hans-Joachim Gabius Herbert Kaltner Christine Decaestecker Robert Kiss Sergio Hassid

BACKGROUND The term nasal polyposis describes benign growth processes in the nasal and sinus mucosa, which are mainly located in the middle meatus and never in the inferior meatus. As a step to define the biochemical determinants relevant for growth regulation, we focused on endogenous lectins known for anti-apoptotic (galectin-3) and immunomodulatory (galectin-1) activities. DESIGN Using com...

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