Glucose-6-phosphate dehydrogenase (G6PD, EC1.1.1.49) is expressed in all tissues where it is the first and rate-limiting enzyme of the pentose phosphate pathway (PPP) [1] that consists of the oxidative and non-oxidative branches and usually works at 1–2% of its maximal potential in healthy subjects due to the high level of nicotinamide adenine dinucleotide phosphate (NADPH). The G6PD gene is wi...

This study was carried out with the aim of evaluating the prevalence of G6PD deficiency, the prevalence of hemolysis with enzyme deficiency and determining the severity of icterus in the hospitalized newborns in our hospital. This prospective descriptive study has been conducted on 1018 icteric newborns admitted to the Bo-Ali Hospital from 2004 to 2007. The dataset included: age, sex, total and...

Purpose: The aim of this study was to investigate in vitro effect glyphosate on Glucose 6-phosphate dehydrogenase (G6PD) enzyme activity.
 Materials and Methods: In terms G6PD deficiency, samples taken from healthy deficient male individuals were studied. After the hemolysates prepared blood sample, enyzme activities determined by modified Beutler method. Then, effects different concentrat...

Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme that initiates pentose phosphate cycle in glucose metabolism. Physiologically, this pathway main source of nicotinamide adenine dinucleotide (NADPH) for red blood cells. This study aims to identify glucose-6-phosphate mutations Nung ethnic patients with G6PD deficiency. 18 pediatric group were diagnosed deficiency at Vietnam National Ch...

G6PD deficiency; Hemolytic anemia; Meta-analysis; Prevalence Abstract Background: Glucose-6-phosphate dehydrogenase (G6PD) is a house keeping enzyme which catalyzes the first step in the hexose monophosphate pathway of glucose metabolism. G6PD deficiency is the commonest hemolytic X-linked genetic disease, which affects approximately 400 million people worldwide. The prevalence rate of G6PD def...

RATIONALE Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, resulting in deficits in nicotinamide adenine dinucleotide phosphate production, an important intracellular antioxidant enzyme. G6PD-deficient subjects present with a susceptibility of erythrocytes to oxidative stress and hemolysis, and should avoid drugs or stressors that have oxidative action...

Background and Aims: This study aimed to investigate the frequency of Q192R polymorphism and oxidative stress markers in infants with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Materials and Methods: This is a case-control study in which 60 male infants (2-4 months old) with G6PD deficiency along with 60 age- and sex-matched healthy neonates were included. The diagnosis of G6PD defic...

background: glucose-6-phosphate dehydrogenase (g6pd) deficiency is one of the most known enzyme defects in iran with various genetic mutations. we aimed to study the predisposing factors of hemolysis in children with g6pd deficiency. methods: this study was done during 2007-2012 in two referral centers of mofid children's hospital and baqiyatallah hospital, tehran, iran. the hospital records of...