BOOK April 29 – 30, 2008 University of Massachusetts, Amherst, MA Edward J. Calabrese, Ph.D. Paul T. Kostecki, Ph.D. Conference Directors

RATIONALE Shear stress (SS) has an established role in atherosclerotic plaque localization, but how it exerts its protective effect is not fully understood. OBJECTIVE To test the hypothesis that SS may downregulate angiotensin type 1 receptors (AT(1)Rs). Angiotensin II has been shown to be proinflammatory and to promote atherosclerosis. METHODS AND RESULTS Using immunohistochemistry, we fou...

EGF receptor internalization, recycling,a nd downregulation were evaluated in liver parenchyma as a function of increasing doses of injected EGF. The effect of ligand occupancy in vivo on the kinetics and extent of internalization was studied with changes in the receptor content of isolated plasmalemma and endosome fractions evaluated by direct binding, Scatchard analysis, and Western blotting....

Elevated CO2 (eCO2) increase plant biomass and might lead to nutritional losses. The results showed that eCO2 under Fe-deficiency stimulates root dry weight from 0.37–0.80 g plant?1 shoot 0.82–2.10 plant?1, without compromising root/shoot ratio. Besides, improved the chlorophyl content of Fe-deficient plants. However, downregulation photosynthesis, reduction in stomatal conductance transpiratio...

Hu W, Mahavadi S, Li F, Murthy KS. Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1 . Am J Physiol Cell Physiol 293: C1991–C2000, 2007. First published October 24, 2007; doi:10.1152/ajpcell.00300.2007.—The pro-inflammatory cytokine IL-1 contributes to the reduced contractile responses of gut smooth muscle observed in both animal...