PURPOSE OF REVIEW Fungal infections of the central nervous system, once a relatively rare occurrence, are increasingly common due to the expansion of immunocompromised populations at risk, and therefore are important to recognize early and manage appropriately. RECENT FINDINGS The specific infectious risk posed by novel immune-modifying therapies can, in most cases, be predicted on the basis ...

Invasive fungal infections are an important cause of morbidity and mortality in hospitalized patients and in the immunocompromised population. This article reviews the current epidemiology of nosocomial fungal infections in adult patients, with an emphasis on invasive candidiasis and aspergillosis. Recently published recommendations and guidelines for the control and prevention of these nosocom...

INTRODUCTION Invasive fungal infections are alarmingly common in intensive care unit patients; invasive fungal infections are associated with increased morbidity and mortality. Risk factors are the increased use of indwelling central venous catheters, the use of broad spectrum antibiotics, parenteral nutrition, renal replacement therapy and immunosuppression. Diagnosis of these infections might...

the incidence of nosocomial fungal infections has increased dramatically during the past two decades as the consequence of continuous increase in the number of severely immunocompromised patients. this study was done to determine the presumptive sources of nosocomial fungal infections at the intensive care unit and transplant wards (in a university- based teaching hospital in tehran) during a 1...

background: onychomycosis results from invasion of the nail plate by dermatophytes, yeasts or mould species of fungi. the objective was to determine the etiological agents of onychomycosis. methods: a total of 549 patients clinically suspected of onychomycosis were examined for causative fungal agents. both di­rect microscopy and the cultures of the nail material were performed to identify the ...

Laboratory techniques Laboratory techniques in the investigation of fungal infections RJ Hay Introduction Fungal infections, mainly in the form of vaginal candidosis, are common in patients attending genitourinary medicine clinics. However, infections affecting the AIDS patient extend this range of fungal disease considerably. The mycoses in AIDS patients include some of the commoner and more i...

Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality.  This study is desig...

With increasing numbers of immune-compromised patients with malignancy, hematologic disease, and HIV, as well as those receiving immunosupressive drug regimens for the management of organ transplantation or autoimmune inflammatory conditions, the incidence of fungal infections has dramatically increased over recent years. Definitive diagnosis of pulmonary fungal infections has also been substan...

UNLABELLED Cutaneous fungal infections are common in Singapore. The National Skin Centre is a tertiary referral centre for dermatological diseases in the country, and sees more than 2,500 cases of superficial fungal infections annually. AIM This study analyses data collated from the centre's medical record office as well as fungal culture results from the mycology laboratory. RESULTS From 1...

To evaluate the efficacy of itraconazole capsules in prophylaxis for fungal infections in neutropenic patients, we conducted a prospective, double-blind, placebo-controlled, randomized trial. Patients with hematologic malignancies or those who received autologous bone marrow transplants were assigned either a regimen of itraconazole (100 mg orally twice daily; n=104) or of placebo (n=106). Over...