During follicular development, a co-ordinated gonadotrophin and endocrine environment is believed to be essential for normal function of the resulting corpus luteum. Whether differences in the gonadotrophins used to promote follicular development can have lasting effects on granulosa cells after they have undergone luteinization and culture, remains to be studied. We measured steroid production...

Fifty-six squirrel monkeys were studied to develop means of accurate ovulation induction. Ovaries were exposed to determine ovulation time. Pre-treatment with progesterone to suppress spontaneous ovulation (5 mg daily for 5 days) was followed by : (a) no fsh, (b) 1 mg fsh, (c) human menopausal gonadotrophin (hmg), equivalent to 75 i.u. fsh, or (d) 200 i.u. pregnant mare's serum gonadotrophin (p...

Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) play an important role in regulating follicle growth and maturation. We have evaluated whether responsiveness to gonadotrophins during an in-vitro fertilization (IVF) treatment is related to follicular fluid IGF-I and IGFBP-3 concentrations. We also investigated if a difference is present in IGF-I and IGFBP-3 concentration...

OBJECTIVE To compare the low-dose recombinant FSH and hMG protocols in treatment of patients with history of severe ovarian hyperstimulation syndrome (OHSS). DESIGN A prospective study on 22 patients with history of severe OHSS. Group A (n = 14) was treated with low-dose recombinant FSH 40 cycles and group B (n = 8) was treated with low-dose hMG in 26 cycles. SETTING The Egyptian IVF-ET Cen...

Abstract Study question Could we stimulate patients of advanced maternal age in the face a shortage HP-hMG without impacting outcomes? Summary answer Given current low availability HP-hMG, it is safe to only with recombinant FSH women affecting results. What known already . Studies on role luteinizing hormone (LH) supplementation undergoing assisted reproductive treatments use different sources...