The recent growth in protein databases has revealed the functional diversity of many protein superfamilies. We have assessed the functional variation of homologous enzyme superfamilies containing two or more enzymes, as defined by the CATH protein structure classification, by way of the Enzyme Commission (EC) scheme. Combining sequence and structure information to identify relatives, the majori...

Protein-protein interactions are usually shown as interaction networks (graphs), where the proteins are represented as nodes and the connections between the interacting proteins are shown as edges. The graph abstraction of protein interactions is crucial for understanding the global behaviour of the network. In this mini review, we summarize basic graph topological properties, such as node degr...

This study addressed the question of how to structure coalitions in order to increase their engagement in multiple strategies for health promotion and consequently to improve their effectiveness. Three structural variables were chosen: (i) coalition's heterogeneity, captured by the professional diversity of its members; (ii) coalition's configuration, defined as the way members were involved in...

Membrane proteins are inserted into the lipid bilayer in bacteria by two pathways. The Sec machinery is responsible for the insertion of the majority of the membrane proteins after targeting by the SRP/FtsY components. However, there is also a class of membrane proteins that insert independent of the Sec machinery. These proteins require a novel protein called YidC. Recently, the structural det...

Glycosyltransferases (GTs), the enzymes that catalyse glycosidic bond formation, create a diverse range of saccharides and glycoconjugates in nature. Understanding GTs at the molecular level, through structural and kinetic studies, is important for gaining insights into their function. In addition, this understanding can help identify those enzymes which are involved in diseases, or that could ...

the steady growing innovations in the area of information and communication technology have raised new concepts and possibilities in different life aspects. in the field of further education and professional training, electronic learning and web-based education are perhaps the most prominent ones. proponents of this technology claim that e-learning courses are at least as effective as correspon...

since takafol is regarded as a product with a structure formed by islamic contracts, its assessment and consideration of stakeholders’ interests as a guarantee of its stability in the insurance market are inevitable. on this basis, in this research, by a comprehensive analysis of the structure and various models of takafol at both general and family levels, we have tried to detect its vulnerabi...

Molecules targeting non-small cell lung cancer driven by activating mutations within the epidermal growth factor receptor (EGFR) are highly effective but acquired drug resistance remains a persistent challenge. Insights from structural pharmacology and medicinal chemistry have aided in detailed understanding of basis for how these inhibitors gain their mutant EGFR selective inhibitory activity ...