We previously have described a group of patients with gluten sensitivity presenting with ataxia (gluten ataxia) and suggested that this disease entity may account for a large number of patients with sporadic idiopathic ataxia. We have therefore investigated the prevalence of gluten sensitivity amongst a large cohort of patients with sporadic and familial ataxia and looked at possible genetic pr...

OBJECTIVES To assess balance and ability to function in patients with spinocerebellar ataxia. METHODS A total of 44 patients with different spinocerebellar ataxia types 1, 2, 3, and 6 were evaluated using the Tinetti balance and gait assessment and the functional independence measure. The scale for the assessment and rating of ataxia and the international cooperative ataxia rating scale were ...

Wernicke’s encephalopathy (WE) is an acute neurological disorder caused by a deficiency in thiamine. It characterized triad of altered mental status, ataxia and ophthalmoplegia. Most the cases reported were secondary to long-term alcohol use. We rare case WE due hyperemesis gravidarum 29-year-old P1L1A1 women at 22 weeks gestation who had spontaneous abortion. Patient manifested with features c...

BACKGROUND The most common neurologic manifestation of gluten sensitivity is ataxia, which accounts for up to 40% of idiopathic sporadic ataxia. Timing of diagnosis of gluten ataxia is vital as it is one of the very few treatable causes of sporadic ataxia and causes irreversible loss of Purkinje cells. Antigliadin antibody (AGA) of the IgG type is the best marker for neurological manifestations...

introduction: loss of inhibitory output from purkinje cells leads to hyperexcitability of the deep cerebellar nuclei (dcn), which results in cerebellar ataxia. also, inhibition of small-conductancecalcium-activated potassium (sk) channel increases firing rate  f dcn, which could cause cerebellar ataxia. therefore, sk channel activators can be effective in reducing the symptoms of this disease, ...

ataxia oculomotor apraxia1(aoa1) is the most frequent cause of autosomal-recessive cerebellar ataxia in japan,but it is reported from all of the world. the presentation is nearly identical to that of at without the non-neurological features,and accounts for up to 10% of autosomal-recessive cerebellar ataxias.gait imbalance and dysarthria are typical presenting features,oculomotor apraxia typica...