UNLABELLED The present study was based on the impact of the superdisintegrants incorporation mechanism on the immediate realese of the tablets final performances. The aim was the selection of the working method to obtain Ranitidine 150 mg tablets with the desiderate quality and in reproducible conditions. MATERIAL AND METHODS The effect of the incorporation mode of sodium starch glycolate on ...

The present work aims at developing mucoahesive tablets of ondansetron hydrochloride using bioadhesive polymers like carbopol-934, sodium alginate and gelatin. Tablets prepared by direct compression using different polymer with varying ratio were evaluated for hardness, friability, uniformity of weight, disintegration time, microenvironmental pH, bioadhesion and in vitro release. Hardness, fria...

The present study aimed to formulate and evaluate sustained release matrix tablets of levofloxacin to achieve sustained drug release with reduced side effects and improved patient compliance. Different batches of sustained release matrix tablets of levofloxacin were prepared by direct compression method using HPMC, sodium CMC and sodium alginate as polymers, Avicel PH 102 (MCC) as filler and st...

Glibenclamide (GBD), also known as glyburide, is an oral hypoglycemic of the sulfonylurea group that is frequently prescribed for the treatment of noninsulin dependent diabetes mellitus. The aim of this study was to assess the pharmaceutical quality of new formulations and four generic marketed glibenclamide tablets in Saudi Arabia in comparison with the innovator product (Daonil tablets). Fria...

Liquisolid systems are an innovative dosage form used for enhancing dissolution rate and improving in vivo bioavailability of poorly soluble drugs. These formulations require specific evaluation methods for their quality assurance (e.g., evaluation of angle of slide, contact angle, or water absorption ratio). The presented study is focused on the preparation, modern in vitro testing, and evalua...

In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. βCyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and βCyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using Diff...

The suitability of the new isomalt grade galenIQ™ 801 for dry granulation and following tableting is evaluated in this study. Isomalt alone, as well as a blend of equal parts with dibasic calcium phosphate, is roll compacted and tableted. Particle size distribution and flowability of the granules and friability and disintegration time of the tablets are determined. Tensile strength of tab...

Purpose: To optimize and formulate promethazine theoclate fast-dissolving tablets that offer a suitable approach to the treatment of nausea and vomiting. Method: The solubility of promethazine theoclate was increased by formulating it as a fast-dissolving tablet containing β-cyclodextrin, crospovidone, and camphor, using direct compression method. A 3 3 full factorial design was used to investi...

Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared sp...

Present research was an attempt to develop a statistical relationship between physicochemical properties of polymers and physical characteristics of fast disintegrating tablets of ibuprofen. Polymers are generally used in formulation to provide effective drug delivery give as well as good physical appearance. Here, several physicochemical properties of three different polymers were calculated a...