Surface-Piercing Propellers (SPPs) have been widely used in high speed craft due to some desirable features such as high efficiency, omission of resistance of equipment attached to the propeller and proper functioning of cavitation. Unlike the submerged propellers, theoretical methods have no significant application on simulation of SPPsbecause of problems related to modeling of these propeller...

Effect of air cushion layer right before impact of a rigid body onto water surface has been investigated in this paper. The study is mainly focused on evaluation of cushioning pressure and the resulting free surface elevation. The air flow is assumed to be an irrotational flow which is governed by Laplace equation. The air problem and the resulting response of the water free surface are suppose...

Progression markers of Parkinson's disease are crucial for successful therapeutic development. Recently, a diffusion magnetic resonance imaging analysis technique using a bitensor model was introduced allowing the estimation of the fractional volume of free water within a voxel, which is expected to increase in neurodegenerative disorders such as Parkinson's disease. Prior work demonstrated tha...

1. The amount of free unfrozen water, i.e. water acting as normal solvent, in frog's muscle at temperatures below the initial freezing-point has been calculated from the vapour pressure isotherm of the muscle. 2. Significant amounts of free water are present at -20 degrees C. The total amount of unfrozen water at -20 degrees C. cannot, therefore, be taken as a measure of the bound water in musc...

There is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson's disease. We previously found elevated free-water levels in the substantia nigra for patients with Parkinson's disease compared with controls in single-site and multi-site cohorts. Here, we test the hypotheses that free-water levels in the substantia nigra of Parkinson's disease increase followin...

The mussel Xenostrobus securis is endemic to the brackish waters of New Zealand and Australia, but has successfully invaded the inner Galician Rías of NW Spain, where it coexists with the indigenous mussel Mytilus galloprovincialis. In this laboratory study, the plasticity of the byssus attachment strength of two mytilids was compared by manipulating substratum, salinity, and bed assembly. M. g...

Low temperature affects the lateral movement of water across the xylem-phloem boundary in intact cotton stems. There is a reduction in the effective diffusion coefficient relating free energy flux to water potential gradients with an associated increase in resistance to water flow. Detached phloem and excised leaves do not show this effect of low temperature. Experiments on stem section halves ...

We present a method which uses DFT (quantum, QM) calculations to improve free energies of binding computed with classical force fields (classical, MM). To overcome the incomplete overlap of configurational spaces between MM and QM, we use a hybrid Monte Carlo approach to generate quickly correct ensembles of structures of intermediate states between a MM and a QM/MM description, hence taking in...

The recent availability of high-resolution structures of two structurally highly homologous, but functionally distinct aquaporins from the same species, namely Escherichia coli AqpZ, a pure water channel, and GlpF, a glycerol channel, presents a unique opportunity to understand the mechanism of substrate selectivity in these channels. Comparison of the free energy profile of glycerol conduction...

Although water molecules are small and only consist of two different atom types, they play various roles in cellular systems. This review discusses their influence on the binding process between biomacromolecular targets and small molecule ligands and how this influence can be modeled in computational drug design approaches. Both the structure and the thermodynamics of active site waters will b...