beta-Amyloid peptide (A beta), the main constituent of senile plaques and diffuse amyloid deposits in Alzheimer's diseased brain, was shown to initiate the development of oxidative stress in neuronal cell cultures. Toxic lots of A beta form free radical species in aqueous solution. It was proposed that A beta-derived free radicals can directly damage cell proteins via oxidative modification. Re...

We study the model of Einstein-Maxwell theory minimally coupling to a massive charged self-interacting scalar field, parameterized by quartic and hexic coupling, labelled $\lambda$ $\beta$, respectively. In absence there is class counterexamples cosmic censorship. Moveover, we investigate properties full nonlinear solution with nonzero argue that, assuming field sufficiently large charge above ...

Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neo...

Although oral glucocorticoids are the treatment of choice for moderate to severe ulcerative pancolitis, their systemic side effects and adrenal suppression account for considerable morbidity. An oral glucocorticoid-conjugate (prodrug), budesonide-beta-D-glucuronide, which is not absorbed in the small intestine but is hydrolysed by colonic bacterial and mucosal beta-glucuronidase to release free...

In 45 cases of trisomy 18 and 493 control pregnancies at 10-14 weeks of gestation, maternal serum inhibin A, total activin A, free beta-hCG and PAPP-A were measured. In the trisomy 18 pregnancies the median values were 0.74 MoM for inhibin A, 1.23 MoM for activin A, 0.38 MoM for free beta-hCG and 0.16 MoM for PAPP-A. The degree of deviation from normal in the levels of inhibin and activin is sm...

Age-associated neurodegenerative disorders are becoming more prevalent as the mean age of the population increases in the United States over the next few decades. Both normal brain aging and Alzheimer's disease (AD) are associated with oxidative stress. Our laboratory has used a wide variety of physical and biochemical methods to investigate free radical oxidative stress in several models of ag...

Human chorionic gonadotropin (hCG) is a clinically relevant marker of trophoblastic and nontrophoblastic malignancies. In the present studies, in addition to determining serum hCG, we investigated the presence and properties of hCG immunoreactivity in ascites of patients with nontrophoblastic malignant tumors and, for comparison, in ascites caused by cirrhotic liver disease. Total hCG immunorea...

We investigate the free energy and entropy of Gaussian massive scalar field theory in static de Sitter space-time for arbitrary temperature. For inverse temperatures form $\ensuremath{\beta}=2\ensuremath{\pi}{2}^{k}$, $k\ensuremath{\in}\mathbf{Z}$, curvature units, we find explicit its derivatives with respect to There are two types contributions energy: one is ``area type'' can be attributed h...

Particle tracks and differential energy loss measured in high pressure gaseous detectors can be exploited for event identification neutrinoless double beta decay~($0\nu \beta \beta$) searches. We develop a new method based on Kalman Filter Bayesian formalism (KFB) to reconstruct meandering of MeV-scale electrons. With simulation data, we compare the signal background discrimination power KFB as...