نتایج جستجو برای: fra evaluation methods
تعداد نتایج: 2519084 فیلتر نتایج به سال:
Metastasis confronts clinicians with two major challenges: estimating the patient's risk of metastasis and identifying therapeutic targets. Because they are key signal integrators connecting cellular processes to clinical outcome, we aimed to identify transcriptional nodes regulating cancer cell metastasis. Using rodent xenograft models that we previously developed, we identified the transcript...
bstract—The protein product of the fra-2 gene (Fra-2), a os-family member, can compete with Fos protein for particpation in activating protein-1 (AP-1) transcription factor omplexes and each protein can contribute different transctivational consequences to an AP-1 complex. To date, here is limited characterization of fra-2 mRNA expression n the rat forebrain. We examined basal and restraint-inu...
Background: Shoes is the first point of contact between the foot and the ground in walking.Any change in that could affect the balance and postural stability. The risks associated with slipping and falling is related to the materials of footwear, surface condition, and geometric design of the shoe sole. The aim of this study was to measure the effect of different shoe sole tread groove ...
Data Grid provides sharing services for very large data around the world. Data replication is one of the most effective approaches to reduce access latency and response time. In addition to the benefits, replication has costs such as storage and bandwidth consumption, especially when storage space is low and limited. Therefore, the data replacement should be done wisely. In this p...
Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis.
OBJECTIVE Systemic sclerosis-associated pulmonary arterial hypertension differs from idiopathic pulmonary arterial hypertension with respect to histopathology, treatment responses and survival. Medical progress on PAH is hampered by the lack of human biosamples and suitable animal models. In this study, the authors evaluated fos-related antigen 2 (Fra-2) transgenic mice as a novel model for sys...
One of the most important methods for transformers fault diagnosis (especially mechanical defects) is the frequency response analysis (FRA) method. The most important step in the FRA diagnostic process is to differentiate the faults and classify them in different classes. This paper uses the intelligent support vector machine (SVM) method to classify transformer faults. For this purpose, two gr...
BACKGROUND Evaluate and compare the utility of serum folate receptor alpha (FRA) and megakaryocyte potentiating factor (MPF) determinations relative to serum CA125, mesothelin (MSLN) and HE4 for the diagnosis of epithelial ovarian cancer (EOC). METHODS Electrochemiluminescent assays were developed for FRA, MSLN and MPF and used to assess the levels of these biomarkers in 258 serum samples fro...
The effect of experimental hematomas on serum levels of fibrinogen-related antigen (FRA) was studied in rabbits. Homologous blood used for production of hematomas was mixed with 131I-fibrinogen, and the measurement of FRA was made using a radioactive technique (representing FRA from hematoma) and immunologically (representing total FRA). Total body radiation of animals bearing hematomas contain...
Accumulating evidence supports the idea that two known phosphatidylinositol 3'-kinase (PI3K) downstream proteins, Fra-1 and Survivin, are potential targets for cancer therapy. Increased expression of Fra-1, a Fos family member of the transcription factor activator protein-1, has been implicated in both the maintenance and the progression of the transformed state of several cancer cells. In addi...
The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 family, is expressed in bone cells, and newborn mice lacking Fra-2 exhibit defects in chondrocytes and osteoclasts. Here we show that Fra-2-deficient osteoblasts display a differentiation defect both in vivo ...
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