نتایج جستجو برای: founder effect
تعداد نتایج: 1647862 فیلتر نتایج به سال:
This paper investigates the effect of founder professional education background on the adoption of the open-science technology management strategy by a sample of 512 young biotechnology firms. One major finding of the paper is that after controlling for founder prior work experience and other organizational and environmental factors, biotechnology firms with proportionally more Ph.D.-holding en...
Whether speciation results more frequently from the genetic consequences of founder events or from gradual genetic divergence of large populations is a matter of debate. In this study, multiple analyses were applied to data from three loci (cytochrome b, alpha-enolase intron VIII, and MHC class II B) to test for founder effects associated with speciation in Aethia (Aves: Alcidae), a genus of se...
This article explores whether new firms managed by founder-chief executive officers (CEOs) are more likely to survive than those successor-CEOs in times of crisis. Drawing on the concept ‘resilience’ adversity, we argue that founder-CEOs increase likelihood firm survival, especially Using a sample Japanese founded during 2003–2010 period, examine impact founder-CEO succession survival. The anal...
Lynch syndrome caused by constitutional mismatch‑repair defects is one of the most common hereditary cancer syndromes with a high risk for colorectal, endometrial, ovarian and urothelial cancer. Lynch syndrome is caused by mutations in the mismatch repair (MMR) genes i.e., MLH1, MSH2, MSH6 and PMS2. After 20 years of genetic counseling and genetic testing for Lynch syndrome, we have compiled th...
BACKGROUND Specific language impairment (SLI) occurs in 2% to 8% of preschool children. Major and candidate genes are probably involved. Genetic drift is a cause for the presence of high frequencies of deleterious alíeles of a specific disease and the founder effect is one of its forms. Robinson Crusoe Island has 633 inhabitants and its actual population began with 8 families that repopulated t...
We screened LRRK2 mutations in exon 41 in 904 parkin-negative Parkinson's disease (PD) patients (868 probands) from 18 countries across 5 continents. We found three heterozygous missense (novel I2012T, G2019S, and I2020T) mutations in LRRK2 exon 41. We identified 11 (1.3%) among 868 PD probands, including 2 sporadic cases and 8 (6.2%) of 130 autosomal dominant PD families. The LRRK2 mutations i...
UNLABELLED PREMISE OF THE STUDY Invasive species are nonnative species that enter novel environments, establish sustained populations, and can negatively impact native species. Here we assess a potential weakness of invasive species (genetic load) and show how species might overcome genetic barriers. Colonization of novel habitats by invasive species typically involves few individuals, expos...
Geneticists have argued that the linear decay in within-population genetic diversity with increasing geographic distance from East Africa is best explained by a phylogenetic process of repeated founder effects, growth, and isolation. However, this serial founder effect (SFE) process has not yet been adequately vetted against other evolutionary processes that may also affect geospatial patterns ...
Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselect...
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