Sertoli cells under the influence of Follicle Stimulating Hormone are known to provide a microenvironment for the growth and differentiation of germ cells. Follicle Stimulating Hormone regulates proliferation of Sertoli cells only during the early neonatal period and during adult period it regulates functional parameters like Transferrin, Androgen binding protein and other factors needed for ge...

evaluation of enlarged follicles with unerupted teeth is always important because some changes may occur. one of the extremely rare conditions seen in dental follicles is multiple calcifying hyperplastic dental follicle. we report a case of multiple calcifying hyperplastic dental follicle. radiographs showed that mandibular third molars had a pericoronal radiolucent zone delineated by a well-de...

The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing int...

Objective(s): Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. Materials and Methods: We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, ...

The ovarian follicle is the fundamental unit of the ovary. It contains the oocyte that may eventually ovulate, undergo fertilization and form an embryo. It also provides the steroid and protein hormones required for maintenance of the ovarian cycle, the secondary sex characteristics and preparation of the uterus for implantation. Follicle formation and folliculogenesis have been well documented...

The hair follicle is a skin appendage with a complex structure containing many cell types that produce highly specialised proteins. The hair follicle is in a continuous cycle: anagen is the hair growth phase, catagen the involution phase and telogen is the resting phase. The follicle offers many potential therapeutic targets. Hoffman and colleagues have pioneered hair-follicle-specific targetin...

A hairy kinase o get a hairy mouse, look to the Sgk3 kinase. So say Alonso et al. on page 559. The control of hair follicle growth has been an enigma for cell biologists. While growth factors such as EGF are known for their ability to stimulate proliferation in epithelial cells, EGF causes hair loss. In addition, the downstream signals that control hair growth are largely unknown. Now, an Akt r...

Follicle development can be divided into gonadotrophin-independent, gonadotrophin-responsive and gonadotrophin-dependent phases. The basic level of control of folliculogenesis lies with the actions of an extensively observed but poorly understood range of somatic and germ cell derived local factors that constitute an intrafollicular developmental cascade that regulates the proliferative and dif...

The mechanism by which one or more dominant ovarian follicles continue development while other subordinate follicles regress is not known. The mitogen activated protein kinases (MAPKs) are a group of kinases that are activated by hormonal factors and form a cascade of processes that regulate cell growth, division and differentiation. The aim of the present experiment was to characterise the pre...

Ovarian follicles form through a process in which somatic pregranulosa cells encapsulate individual germ cells from germ cell syncytia. Complementary expression of the Notch ligand, Jagged1, in germ cells and the Notch receptor, Notch2, in pregranulosa cells suggests a role for Notch signaling in mediating cellular interactions during follicle assembly. Using a Notch reporter mouse, we demonstr...