Plasma clearance of folie acid was studied in 25 patients, 19 of whom were selected early cases of malignancy with unimpaired general condition; 23 of these patients, including 17 with early tumors, had an accelerated clearance rate. On an average, the clearance of folie acid in plasma was more rapid in patients with low serum iron or hemoglobin concentration. Pathologic values for the FIGLI"2 ...

The purpose of this study was to determine the influence of folie acid or vitamin B-12 on the course of the IRC 741 rat leukemia treated with thioTEPA. On the first day im mediately following tumor implantation into Fischer rats individual series of these ani mals were given 6 mg/kg thioTEPA, in a single injection, or 1 mg/kg, every other day for six doses without and with simultaneous injectio...

Background: Delusional syndromes may appear in different psychiatric disorders as schizophrenia, dementia or other psycho-organic syndromes. While single delusional phenomena are rather common, combined syndromes of delusional symptoms rarely occur. Samplings and methods: The authors present a case including different delusional misidentification syndromes and other delusional phenomena in one ...

The combined action among polyglutamylatable and nonpolyglutamylatable antifolates, directed against dihydrofolate reducÃ-ase (DHFR), glycinamide ribonucleotide formyltransferase (GARFT), 5-aminoimidazole4-carboxamide ribonucleotide formyltransferase (AICARFT), and thymidylate synthase (TS), in human ileocecal HCT-8 cells was examined in a 96-well plate growth inhibition assay (96-h continuous ...

It has been observed that folie acid (2) or citrovorum factor (1) will prevent the anti-leukemic ac tion of folie acid antagonists. We have reported that desoxyribonucleic acid (5) and vitamin Bi2 (7) will partially prevent the anti-leukemic action of 4-aminopteroylglutamic acids, and have more re cently observed that a combination of thymidine, adenylic, guanylic, and cytidylic acids or DNA pl...

Dans cette étude, les pratiques de travail social menées en Turquie après 1923 seront systématiquement discutées dans une perspective chronologique. Il y a deux points importants qui distinguent étude des études précédentes. Le premier ces est que traitée structure chronologique différente et discutée avec critique. Un autre point rédigée français, contrairement aux langues précédemment publiée...