نتایج جستجو برای: fndc5 protein

تعداد نتایج: 1234898  

Journal: :Clinical and translational discovery 2023

Obesity and its associated comorbidities such as type 2 diabetes cardiovascular diseases are – despite all the current efforts in research still difficult to tackle therapeutically. For people struggling with body weight, diet physical activity can have profound beneficial effects. The main benefit of exercise is rendering a negative energy balance by skeletal muscle usage carbohydrates lipids....

2017
Young Jin Jang Hyo Jeong Son Yong Min Choi Jiyun Ahn Chang Hwa Jung Tae Youl Ha

Apigenin, a natural flavone abundant in various plant-derived foods including parsley and celery, has been shown to prevent inflammation and inflammatory diseases. However, the effect of apigenin on skeletal muscle hypertrophy and myogenic differentiation has not previously been elucidated. Here, we investigated the effects of apigenin on quadricep muscle weight and running distance using C57BL...

2017
Lakshminarasimhan Sundarrajan Chanel Yeung Logan Hahn Lynn P Weber Suraj Unniappan

Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha). We aimed to study the role of irisin on cardiac function and muscle protein regulation in zebrafish. Western blot analyses det...

2015
Natalia Wawrusiewicz-Kurylonek Beata Telejko Mariusz Kuzmicki Angelika Sobota Danuta Lipinska Justyna Pliszka Beata Raczkowska Pawel Kuc Remigiusz Urban Jacek Szamatowicz Adam Kretowski Piotr Laudanski Maria Gorska Rudolf Kirchmair

AIM The aim of the study was to compare maternal and cord blood levels of betatrophin--a new peptide potentially controlling beta cell growth--as well as in its mRNA expression in subcutaneous adipose tissue, visceral adipose tissue and placental tissue obtained from pregnant women with normal glucose tolerance (NGT) and gestational diabetes (GDM). METHODS Serum betatrophin and irisin concent...

2013
Marta G. Novelle Cristina Contreras Amparo Romero-Picó Miguel López Carlos Diéguez

In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene family. Major interest in this protein arose bec...

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