نتایج جستجو برای: fmdv

تعداد نتایج: 872  

Journal: :Vaccine 2003
Mauro P Moraes Jarasvech Chinsangaram Mario C S Brum Marvin J Grubman

We have previously shown that swine inoculated with recombinant, replication-defective human adenovirus type 5 containing the porcine interferon alpha gene (Ad5-pIFNalpha) are completely protected when challenged 1 day later with virulent foot-and-mouth disease virus (FMDV). In the current study, we examined the duration of protection afforded swine by Ad5-pIFNalpha and the ability of a combina...

Journal: :Molecular and cellular probes 2010
Scott M Reid Kenneth E Pierce Rohit Mistry Sukvinder Bharya Juliet P Dukes Carmelo Volpe Lawrence J Wangh Donald P King

A reverse transcription Linear-After-The-Exponential polymerase chain reaction (RT LATE-PCR) assay was evaluated for detection of foot-and-mouth disease virus (FMDV). This pan-serotypic assay targets highly conserved sequences within the 3D (RNA polymerase) region of the FMDV genome, and uses end-point hybridisation analysis of a single mismatch-tolerant low temperature probe to confirm the ide...

2010
Juan M. Pacheco P. W. Mason

Most isolates of foot-and-mouth disease virus (FMDV) display a broad host range. Since the late 1990s, the genetic lineage of PanAsia topotype FMDV serotype O has caused epidemics in the Far East, Africa, the United Kingdom, France, the Netherlands, and numerous other countries throughout Europe and Asia. In contrast, there are several FMDV isolates that exhibit a more restricted host range. A ...

2011
Mustafa Yavuz Gulbahar Yonca Betil Kabak Mehmet Onder Karayigit Murat Yarim Tolga Guvenc Unal Parlak

This study describes the expression of heat shock protein70 (HSP70) and alpha-basic-crystallin (α-BC) and their association with apoptosis and some related adaptor proteins in the pathogenesis of foot-and-mouth disease virus (FMDV)-induced myocarditis in lambs. HSP70 was generally overexpressed in the myocardial tissues and inflammatory cells of FMDV-induced myocarditis with differential accumu...

Journal: :Virology 2013
Juan M Pacheco Douglas P Gladue Lauren G Holinka Jonathan Arzt Elizabeth Bishop George Smoliga Steve J Pauszek Alexa J Bracht Vivian O'Donnell Ignacio Fernandez-Sainz Paige Fletcher Maria E Piccone Luis L Rodriguez Manuel V Borca

The role of non-structural protein 3A of foot-and-mouth disease virus (FMDV) on the virulence in cattle has received significant attention. Particularly, a characteristic 10-20 amino acid deletion has been implicated as responsible for virus attenuation in cattle: a 10 amino acid deletion in the naturally occurring, porcinophilic FMDV O1 Taiwanese strain, and an approximately 20 amino acid dele...

2013
James J. Zhu Jonathan Arzt Michael C. Puckette George R. Smoliga Juan M. Pacheco Luis L. Rodriguez

Foot-and-mouth disease virus (FMDV) targets specific tissues for primary infection, secondary high-titer replication (e.g. foot and mouth where it causes typical vesicular lesions) and long-term persistence at some primary replication sites. Although integrin αVβ6 receptor has been identified as primary FMDV receptors in animals, their tissue distribution alone fails to explain these highly sel...

2008
B. Borrego J. M. Argilaguet E. Pérez-Martín A. Ezquerra M. Pérez-Filgueira J. M. Escribano F. Sobrino F. Rodríguez

In this report we present some preliminary results obtained with the last generation of DNA vaccines based on FMDV minigenes designed in our laboratory. Using previously characterised FMDV Band T-cell epitopes, we have tested several targeting signals as carriers for our vaccine antigens. From the different molecules assayed, the signal peptide from the CCL20 porcine chemokine showed to be very...

2013
Yan Zhang Yingjun Sun Fan Yang Jianhong Guo Jijun He Qiong Wu Weijun Cao Lv Lv Haixue Zheng Zhidong Zhang

The mechanism by which the foot-and-mouth disease virus (FMDV) initiates infection of cells is thought to involve the attachment of the viral capsid to host integrins on the surface of target cells. However, the role of integrins in FMDV infection still needs to be fully understood, although it has been demonstrated that integrin αvβ6 interferes with FMDV in vitro and results in neutralization ...

2008
M. F. Chaudhury G. B. Ward S. R. Skoda M.Y. Deng J. B. Welch T. S. McKenna

Experiments were done to determine if transporting live screwworms Cochliomyia hominivorax Coquerel (Diptera: Calliphoridae) for developing new strains from countries where foot-and-mouth disease and classical swine fever are endemic, to the mass rearing facilities in Mexico and Panama, may introduce these exotic diseases into these countries. Are screwworms capable of harboring and spreading f...

Journal: :iranian journal of virology 0
a ahmadi-vasmehjani department of microbiology, jahrom university of medical sciences, jahrom, iran sd mousavi-nasab department of virology, faculty of medical sciences, tarbiat modares university, tehran, iran r baharlou department of microbiology, jahrom university of medical sciences, jahrom, iran f jeirani department of fmd, razi vaccine and serum research institute, karaj, iran m shayestehpour department of virology, tehran university of medical sciences, tehran, iran s yaghoubi department of microbiology, tehran university of medical sciences, tehran, iran

background and aims: accurate and rapid diagnosis is necessary for effective control and prevention of foot-and-mouth disease (fmd). in present study, was evaluated real time reverse transcription-polymerase chain reaction (rrt-pcr) assay along with diagnostic routine methods for the detection of all seven serotypes of fmd virus (fmdv), namely o, c, a, sat1, 2, 3 and asia 1 in biological sample...

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