UNLABELLED This work addresses the issue of using (18)F-FDG PET in patients with renal failure. METHODS A model analysis has been developed to compare tissue (18)F-FDG uptake in a patient who has normal renal function with uptake in a theoretic limiting case that assumes tracer plasma decay is tracer physical decay and is trapped irreversibly. RESULTS This comparison has allowed us to propo...

In the present issue of the J Nucl Med, Orlhac and colleagues present a study comparing visual assessment of uptake heterogeneity in positron emission tomography (PET) images by experts and a subset of radiomics metrics, namely textural features (TF). They exploited both clinical and simple simulated PET images, going further than previous studies carried out using clinical data only (4–6). Suc...

[This corrects the article DOI: 10.1371/journal.pone.0161845.].

INTRODUCTION The use of fluorodeoxyglucose-positron emission tomography to evaluate well-differentiated hepatocellular carcinomas is facing critical problems. It is reported that the activity of fluorodeoxyglucose-6-phosphatase, which converts fluorodeoxyglucose-6-phosphatase to fluorodeoxyglucose, is high in normal liver cells. However, the enzyme-converting activity of glucose-6-phosphatase o...

Institute of Nuclear Medicine, University College London, London, UK Kinetic analysis can be applied both to dynamic PET and dynamic contrast enhanced (DCE) MRI data. We have investigated the potential of combined PET-MRI kinetic modelling using simulated FDG data. The volume of distribution, Ve, for the extravascular extra-cellular space (EES) can be estimated by DCE-MRI, and used to reduce th...

CONCLUSION We have demonstrated differences in cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. The differences in cortical processing patterns between these two cases may have been influenced by the differing clinical courses and pathogenesis of hearing loss due to genetic mutations. Our results sugg...

Although [18F] 2-fluoro-2-deoxy-D-glucose (FDG) is the most widely used radiopharmaceutical the world over, it is not the ideal tracer for brain imaging, owing to its high physiological cortical uptake and lack of specificity. This has paved the way for the introduction of several novel radiotracers, each with their own inherent strengths and limitations. We present the insights gained from the...

The use of fluorodeoxyglucose positron emission tomography (FDG-PET) for the evaluation of tumor response to chemotherapy and radiation therapy has been studied in a number of malignancies. By imaging tumor metabolism and therapy-related changes, FDG-PET has demonstrated advantages over anatomical imaging in the assessment of treatment response. More recent investigations have indicated that FD...

1Institute of Imaging Science, Departments of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee; 2Departments of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee; 3Department of Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee; 4Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee; and 5Depar...

UNLABELLED Global spatial normalization transforms a brain image so that its principal global spatial features (position, orientation and dimensions) match those of a standard or atlas brain, supporting consistent analysis and referencing of brain locations. The convex hull (CH), derived from the brain's surface, was selected as the basis for automating and standardizing global spatial normaliz...