Hemodynamic shear stress from blood flow on the endothelium critically regulates vascular function in many physiological and pathological situations. Endothelial cells adapt to shear stress by remodeling their cytoskeletal components and subsequently by changing their shape and orientation. We demonstrate that β1 integrin activation is critically controlled during the mechanoresponse of endothe...

In this paper we demonstrate an unusual behavior in the shear-banded flow of a viscoelastic fluid. We report large and patterned fluctuations in the shear stress in an apparently fluid material undergoing steady shear, which we interpret as an intermittent and microscopic fracture and self-healing process. The statistical pattern of the fluctuations is indicative of self-organized criticality, ...

Wall-shear stress results from the relative motion of a fluid over a body surface as a consequence of the no-slip condition of the fluid in the vicinity of the wall. To determine the two-dimensional wall-shear stress distribution is of utter importance in theoretical and applied turbulence research. In this article, characteristics of the Micro-Pillar Shear-Stress Sensor MPS(3), which has been ...

Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear stress activates the Rho downstream effectors ROCK, LIM kinase (LIMK), and cofili...

Fluid shear stress alters the morphology and function of the endothelium by activating several kinases. Furthermore, shear stress potently inhibits apoptosis of endothelial cells. Since activation of Akt kinase has been shown to prevent cell death, we investigated the effects of shear stress on Akt phosphorylation. To test the hypothesis that shear stress interacts with the Akt kinase pathway, ...

Fluid shear stress modulates vascular function and structure by stimulating mechanosensitive endothelial cell signal events. Cell adhesion, mediated by integrin-matrix interactions, also regulates intracellular signaling by mechanosensitive events. To gain insight into the role of integrin-matrix interactions, we compared tyrosine phosphorylation and extracellular signal-regulated kinase (ERK1/...

Fluid shear stress has profound effects on cell physiology. Here we present a versatile microfluidic method capable of generating variable magnitudes, gradients, and different modes of shear flow, to study sensory and force transduction mechanisms in cells. The chip allows cell culture under spatially resolved shear flow conditions as well as study of cell response to shear flow in real-time. U...

The present paper deals with a two-layered mathematical model for blood flow through stenotic tube in porous medium under the effect of an applied magnetic field. In this mathematical model, the blood is considered as Newtonian fluid of variable viscosity in the central region and plasma fluid which is considered as Newtonian fluid of constant viscosity in the peripheral region of the stenotic ...

New exact solutions for unsteady magnetohydrodynamic MHD flows of an Oldroyd-B fluid have been derived. The Oldroyd-B fluid saturates the porous space. Two different flow cases have been considered. The analytical expressions for velocity and shear stress fields have been obtained by using Laplace transform technique. The corresponding solutions for hydrodynamic OldroydB fluid in a nonporous sp...

An attempt has been made to investigate the wall shear stress, resistance parameter and flow rate across mild stenosis situated symmetrically on steady blood flow through blood vessels with uniform or non-uniform cross-section by assuming the blood to be Non-Newtonian, incompressible and homogeneous fluid. An analytic solution for Power law Fluid, Bingham Plastic fluid, Casson Fluid has been ob...