BACKGROUND The size and geometry of an insulin depot that is formed during subcutaneous administration by an insulin pump is evaluated. A novel method is used to visualize accurately the depot formation for small volumes of insulin (of the order of 10-100 µl) at a given point in time. Conventional visualization methods such as magnetic resonance imaging are unable to provide such accurate measu...

Due to drops in orders and decreasing production rates, demand is declining seriously in many logistic sectors like e.g. air cargo, ship and less-than-truckload (LTL) transports. Hence, logistic companies are looking for new ways to improve their transportation network efficiency. On the operational level, costs depend mainly on planned delivery tours. In our current research project KolOptNet1...

Inspired by a real-life case in the Brussels Capital Region, Belgium, this paper provides Memetic Algorithm with Sequential Split procedure (MASS) for solving large variety of waste collection problems multiple depots, restricted vehicle fleet at each depot, (intermediate) processing facilities, capacity restrictions per facility and partial pick-ups. MASS first generates satisfactory initial s...

Many space applications require robotic manipulators which have large workspace and are capable of precise motion. Micro-macro manipulators are considered as the best solution to this demand. Such systems consist of a long flexible arm and a short rigid arm. Kinematic redundancy and presence of unactuated flexible degrees of freedom, makes it difficult to control micro-macro manipulators. This ...

AIMS The aim was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of octreotide subcutaneous (s.c.) depot, a novel octreotide formulation. METHODS This was a phase I, randomized, open label study. After a single dose of octreotide immediate release (IR) 200 µg, subjects were randomized to one of eight groups to receive three monthly injections of octreotide s.c. depot...

In this paper we present a strategy for optimizing end-toend TCP/IP throughput over long-haul networks (i.e. those where the product of the bandwidth and the delay is high.) Our approach defines a Logistical Session Layer (LSL) that uses intermediate process-level “depots” along the network route from source to sink to implement an end-to-end communcation session. Despite the additional process...

Among numerous NP-hard problems, the Traveling Salesman Problem (TSP) has been one of the most explored, yet unknown one. Even a minor modification changes the problem’s status, calling for a different solution. The Generalized Traveling Salesman Problem (GTSP)expands the TSP to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...

This paper evaluates a new and simple controller design method based on QFT (quantitative feedback theory) for a two-link manipulator whose first link is rigid and the second is flexible. A piezoelectric patch is attached to the surface of the flexible link for vibration suppression of it. This system is modeled as a nonlinear multi-input multi-output (MIMO) control systems whose inputs are two...

Data center networks are considered to make use of the computing and storage resources in data centers, which include intra-datacenter and inter-datacenter networks. Both of them will depend on the optical networking due to its advantages, such as low latency, high bandwidth, and low energy consumption. Data center interconnected by flexi-grid optical networks is a promising scenario to allocat...