Two flavonids: 5-hydroxy-6,7,4 ́-trimethoxy flavone (salvigenin), 5-hydroxy-7,4 ́-dimethoxy flavone(thitonine) and a labdane type diterpenoid: 8,13-epoxy-14 labdene (manoyl oxide) isolated from the solventextract of the aerial part of Salvia reuterana Boiss.The proposed structure were stablished by 1HNMR,13CNMR, 2DNMR( C-H-Cosy, HMQC),DEPT and Mass spectroscopy and confirmed in accordance withbib...

Over 4000 flavonoids have been identified so far and among these, many are known to have antitumor activities. The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. Here we report the differential cytotoxic effects of two flavone isomers on human cancer...

Flavonoids constitute a large class of polyphenolic compounds with cancer preventative properties. We have examined the ability of the natural flavone diosmetin to inhibit proliferation of breast adenocarcinoma MDA-MB 468 and normal breast MCF-10A cells and found that this compound is selective for the cancer cells with slight toxicity in the normal breast cells. Diosmetin was metabolised to th...

I . The oxidative stability of lipids in the tissues (erythrocytes, liver and depot fat) from vitamin E-deficient rats was not improved by feeding these animals, for a period of 39-55 days before killing, on a vitamin E-free diet richly supplemented with the flavonoid antioxidants quercetin (3,s ,7,3’,4’-pentahydroxyflavone) and flavone (3,7,8,~’,5’-pentahydroxy-6tert.-butyl flavone). z. Additi...

Flavonoids and isoflavonoids are major plant secondary metabolites that mediate diverse biological functions and exert significant ecological impacts. These compounds play important roles in many essential physiological processes. In addition, flavonoids and isoflavonoids have direct but complex effects on human health, ranging from reducing cholesterol levels and preventing certain cancers to ...

Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in different mouse tumor models. Root-specific flavones (RSFs) from Scutellaria hav...

The flavonoids 5,6,7,8,9-hydroxy chalcone, 3,7-hydroxy-4?methoxy flavone, 5,6,7,8-hydroxy-4?-methoxy flavone and 3,5,6,7,4?-hydroxy flavone can be detected only in non-mycorrhizal roots of white clover, but not in mycorrhizal roots, whereas the flavonoids acacetin, quercetin and rhamnetin are only present in mycorrhizal roots. We tested the effect of several concentrations of these compounds on...

Columnidin, the characteristic 3-deoxyanthocyanidin of some Columnea species, possesses the 3',4'-B-ring hydroxylation pattern of luteolinidin and an additional hydroxyl group at the A-ring, most likely in the 8-position. Studies on substrate specificity of chalcone synthase and flavanone 4-reductase and the demonstration of high flavonoid 3'-hydroxylase activity revealed that the 3'-hydroxyl g...

Angiogenesis is an effective target in cancer control. The antiangiogenic efficacy and associated mechanisms of acacetin, a plant flavone, are poorly known. In the present study, acacetin inhibited growth and survival (up to 92%; P < 0.001), and capillary-like tube formation on Matrigel (up to 98%; P < 0.001) by human umbilical vein endothelial cells (HUVEC) in regular condition, as well as VEG...