Purpose: The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence of ERG overexpression in prostate cancer cells due to TMPRSS2-ERG fusions suggest for causal roles of ERG protein in the neoplastic process. TMPRSS2-ERG fusion junctions have been extensively studied in prostate cancer. However, virtually nothing is known about the n...

ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations.We describe clinical and genomic features of the ERG-related cases in ...

The endothelial ETS transcription factor Erg plays an important role in homeostasis and angiogenesis by regulating many endothelial functions including survival and junction stability. Here we show that Erg regulates endothelial cell (EC) migration. Transcriptome profiling of Erg-deficient ECs identified ∼ 80 genes involved in cell migration as candidate Erg targets, including many regulators o...

Using the Chandra ACIS-I instruments, we have carried out the deepest X-ray observation on a typical Galactic plane region at l ≈ 28.5, where no discrete X-ray sources have been known previously. We have detected, as well as strong diffuse emission, 275 new point X-ray sources (4 σ confidence) within two partially overlapping fields (∼250 arcmin in total) down to ∼ 3×10 erg s cm (2 – 10 keV) or...

The spectroscopic analysis of 117 serendipitous sources in the HELLAS2XMM 1df (1 degree field) survey is described. Of these, 106 sources, of which 86% have a spectroscopic redshift, are used to evaluate the fraction of X-ray absorbed (log NH>22) Active Galactic Nuclei (AGN) in the 2–10 keV flux range 0.8–20×10 −14 erg cm s. This fraction turns out lower than what is predicted by two well known...

We present XMM-Newton observations of two hyperluminous IRAS galaxies (LBol > 10h 50 L⊙), neither of which was previously detected by ROSAT. Published models of the infrared spectral energy distributions imply that a starburst and obscured quasar contribute equally to the power of each source. IRAS F12514+1027 (z = 0.30) is detected in 18.6 ks with 130 EPIC-pn counts over 0.2-12 keV. The soft X...

NGC 247 is a nearby late-type bulgeless spiral galaxy that contains an inactive nucleus. We report a serendipitous discovery of an X-ray flare from the galaxy center with a luminosity of up to 2 1039 ́ erg s in the 0.3–10 keV band with XMM-Newton. A Chandra observation confirms that the new X-ray source is spatially coincident with the galaxy nucleus. The XMM-Newton data revealed a hard power-la...

We present the first high resolution X-ray image of the dwarf elliptical galaxy NGC 3226. The data were obtained during an observation of the nearby Seyfert Galaxy NGC 3227 using the Chandra X-ray Observatory. We detect a point X-ray source spatially consistent with the optical nucleus of NGC 3226 and a recently-detected, compact, flat-spectrum, radio source. The X-ray spectrum can be measured ...

Hypoxic stress is a risk factor of ocular neovascularization. Hypoxia visualization may provide clues regarding the underlying cause of angiogenesis. Recently, we developed a hypoxia-specific probe, protein transduction domain-oxygen-dependent degradation domain-HaloTag-Rhodamine (POH-Rhodamine). In this study, we observed the localization of HIF-1α proteins by immunohistochemistry and the fluo...