Bacillus subtilis implements several adaptive strategies to cope with nutrient limitation experienced at the end of exponential growth. The DegS-DegU two-component system is part of the network involved in the regulation of postexponential responses, such as competence development, the production of exoenzymes, and motility. The degU32(Hy) mutation extends the half-life of the phosphorylated fo...

Our laboratory in The Gambia, West Africa, performs Koga agar (1.5% bacteriological agar, 0.5% sodium chloride, 0.5% meat extract, 0.1% bacteriological peptone) culture for larvae of strongyle nematodes on human fecal samples for which parasitological investigation has been requested. We have recovered freeliving amoebae (FLA) from human fecal specimens on two occasions over a period of 9 month...

Objective(s): Pseudomonas aeruginosa infections such as keratitis are considered among the major health problems worldwide due to the complexity of pathogenesis and antibiotic resistance crisis, thus, finding new effective approaches for prevention and treatment of the infections seem to be still vital. In this report, we aimed to investigate the therapeutic effects of topical administration of...

Infections caused by free-living amebae (FLA) are severe and life-threatening. These infections include primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri and granulomatous amebic encephalitis caused by Balamuthia mandrillaris and Acanthamoeba species. Although several drugs have in vitro activity against FLA, mortality from these infections remains>90% despite treatment with ...

Thirteen relapsed or refractory AML patients were treated with the FLA regimen. A complete remission was observed in 54% of cases but the median duration of remission was short (4 months). These results suggest that the FLA regimen is not able to induce a durable complete remission in the poor-risk AML patients.

This book deals with all aspects of human immuno-deficiency virus infection and the Acquired Immune Deficiency Syndrome. It includes chapters describing the human immuno-deficiency in detail, clinical features of HIV infection of various systems and opportunistic infections which occur in patients rendered immuno -deficient. It also includes useful chapters concerned with special problems relat...

BACKGROUND The reservoir and mode of transmission of Mycobacterium ulcerans, the causative agent of Buruli ulcer, still remain a mystery. It has been suggested that M. ulcerans persists with difficulty as a free-living organism due to its natural fragility and inability to withstand exposure to direct sunlight, and thus probably persists within a protective host environment. METHODOLOGY/PRINC...