نتایج جستجو برای: fibroblast like synoviocytes
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INTRODUCTION Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the expression of chemerin and ChemR23 in the synovium of rheumatoid arthritis (RA) patients and the stimulatory effects of chemerin on fibroblast-like synoviocytes (FLSs) from RA patients. METHODS Chemerin and ChemR23 express...
Proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 (IL-1), mediate the joint destruction that characterizes rheumatoid arthritis (RA). Previous studies have shown that parathyroid hormone-related protein (PTHrP) is a member of the cascade of proinflammatory cytokines induced in parenchymal organs during lethal endotoxemia. To test the hypothesis that NH2-terminal...
Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there no cure for OA. Fucoidans, one of main therapeutic components brown algae, have emerged as promising molecules in OA treatment. However, variability between fucoidans makes difficult pursuit suitable candidate target specific pathological processes. By an vitro experimental approach chondrocytes and fib...
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