A MAJOR theory as to the pathogenesis of atherosclerosis considers the necrotic and calcine vascular changes to be secondary to repeated thromboses ineffectively neutralized by normal fibrinolytic processes. Duguid and Robertson have presented evidence indicating that many of the lesions we classify as atherosclerosis are arterial thrombi which, by the ordinary process of organization, have bee...

INTRODUCTION Postoperative adhesions after abdominal or pelvic surgery remain an important clinical problem causing infertility, pain and bowel obstruction. Their prevention and treatment remains poorly understood and inadequate. The formation of adhesions is caused by the organization of a fibrin matrix, an organization that takes place during the coagulation process when there is suppression ...

• Since Virchow's observation o idity and incoagulability of cadaver capillaries and veins, a number of re indicated that this phenomenon is cau postmortem fibrinolysis. Mole suggest the vascular endothelium is a source fibrinolytic activity in cadaver blood. Kwaan et al.' applied stimuli to in man and in rabbits and obse lease of fibrinolytic activity thr< cholinergic mechanism. Release o acti...

The rate of digestion of fibrin was measured in vitro by an isotopic technique in 140 blood samples of differing fibrinogen concentration; the assessment of fibrinolytic activity thus obtained was compared with a standard method of measurement, the dilute whole blood lysis time. The lysis time was related exponentially to the fibrinolytic activity as measured by the isotopic technique, and furt...