BACKGROUND Fibrinogen (Fg) has been considered essential for platelet aggregation. However, we recently demonstrated formation of occlusive thrombi in Fg-deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF(-/-)). METHODS AND RESULTS Here we studied Fg/VWF-independent platelet aggregation in vitro and found no aggregation in citrated platelet-rich plasma of Fg/...

Haemophilus ducreyi is the etiologic agent of the sexually transmitted genital ulcer disease chancroid. In both natural and experimental chancroid, H. ducreyi colocalizes with fibrin at the base of the ulcer. Fibrin is obtained by cleavage of the serum glycoprotein fibrinogen (Fg) by thrombin to initiate formation of the blood clot. Fg binding proteins are critical virulence factors in medicall...

This study adopts the Keller’s ARCS (Attention, Relevance, Confidence, and Satisfaction) motivational design framework to develop instructional strategies to integrate educational game learning into formal classroom settings. The experimental instruction lasts 8 weeks and there are 103 students in 6 grader involved. From the result of students’ opinions, motivational instruction strategies deve...

Thrombospondin-1 (TSP) may, after secretion from platelet alpha granules, participate in platelet aggregation, but its mode of action is poorly understood. We evaluated the capacity of TSP to form inter-platelet cross-bridges through its interaction with fibrinogen (Fg), using either Fg-coated beads or Fg bound to the activated GPIIbIIIa integrin (GPIIbIIIa*) immobilized on beads or on activate...

We study theoretically the collective dynamics of immotile particles bound to a 2D surface atop a 3D fluid layer. These particles are chemically active and produce a chemical concentration field that creates surface-tension gradients along the surface. The resultant Marangoni stresses create flows that carry the particles, possibly concentrating them. For a 3D diffusion-dominated concentration ...

The combined efficacy of space- and alertness related training in chronic hemineglect was tested behaviorally and in a longitudinal fMRI study. Earlier results had shown that both space as well as alertness related training as single intervention methods lead to short term improvement which, however, is not stable for longer time periods. The neurobiological data obtained in these studies revea...

In this paper, we have reported a low-concentration active electrolyte of KBrO3 for the supercapacitor’s application. The electrochemical processes were carried out in two concentrations with 0.2 and 0.4 M. Additionally, novel strategy doping graphene during its fabrication process potassium bromide (KBr) solution. chemical KBr improved properties used as supercapacitors. HRTEM images confirmed...

Abstract An investigation of dynamic behaviors a sandwich plate containing an imperfect two dimensional functionally graded (2D-FG) core surrounded by faces on two-parameter elastic foundation and subjected to moving load is carried out in this paper. The present solid composed porous 2D-FG covered homogenous layers. It assumed that the middle layer has micro voids dispersed uniformly unevenly ...