BACKGROUND To investigate the differences in cardiovascular disease, extracardiac anomalies and outcomes between fetuses with levocardia and dextrocardia. METHODS Clinical demographics, prenatal features, postnatal characteristics and the outcomes of fetuses with levocardia or dextrocardia were recorded and analyzed. RESULTS Sixty-five fetuses with dextrocardia and thirty-eight fetuses with...

In this study, we examined chronic norepinephrine suppression of insulin secretion in sheep fetuses with placental insufficiency-induced intrauterine growth restriction (IUGR). Glucose-stimulated insulin secretion (GSIS) was measured with a square-wave hyperglycemic clamp in the presence or absence of adrenergic receptor antagonists phentolamine (alpha) and propranolol (beta). IUGR fetuses were...

serum glucose levels (18±2 mg/dl, P <0.001) and serum insulin levels (12±3 IAU/ml, P < 0.001) in six chronically catheterized control fetuses of the same gestational ages. Glucose infusion to the fetuses did not alter maternal serum glucose (60±3 mg/dl) or serum insulin levels (35±5 MAU/ml). Arterial blood gases (pH 7.34±0.01, Po2 24.3±0.5 mmHg, Pco2 41.5±0.9 mmHg), oxygen saturation (73±2%), h...

BACKGROUND A fetus exposed to maternal anti-SSA/Ro or anti-SSB/La antibodies (or both) may develop complete atrioventricular block (AVB), which results in high prenatal and postnatal morbidity and mortality. Until recently, only high-grade AVB could be diagnosed in utero. The tissue velocity-based fetal kinetocardiogram (FKCG) enables accurate measurement of AV conduction time and diagnosis of ...

Background Limited information is available regarding the prevalence and outcomes of fetal tachyarrhythmias from the developing countries. Aims This study aims to report referral patterns, management protocols, and pregnancy outcomes of fetuses with tachyarrhythmias reporting to a single center in South India. Methods All fetuses with documented sustained fetal tachyarrhythmia during the st...

Eukaryotic species commonly contain a diploid complement of chromosomes. The diploid state appears to be advantageous for mammals because it enables sexual reproduction and facilitates genetic recombination. Nonetheless, the effects of DNA ploidy on mammalian ontogeny have yet to be understood. The present study shows phenotypic features and expression patterns of imprinted genes in tripronucle...

BACKGROUND Slight morphological asymmetry of the cerebral hemispheres has been observed in fetal and newborn brains. In adults, sex differences in hemispheric asymmetry have also been reported. OBJECTIVE To establish whether cerebral hemisphere asymmetry correlates with sex in fetuses. METHODS Left-right cerebral hemisphere asymmetry, and the correlation with sex, were studied in 51 male an...

Objective: To evaluate the blood flow of umbilical vein and right portal in macrosomic fetuses diabetic mothers investigate effect maternal insulin treatment on these flows. Material Methods: This prospective case-control study was conducted between March 2019 December 2019. Fetuses 49 pregestational gestational who had an abdominal circumference percentile above 97% were evaluated as formed gr...

OBJECTIVE To review the outcomes of 193 fetuses with cardiac abnormalities detected by echocardiography. METHODS A total of 422 fetuses between 16 and 41 gestational weeks, referred to paediatric cardiologists for detailed echocardiography, were included in this study. RESULTS Structural heart defects were found in 55 (28%), isolated arrhythmia in 105 (54%), and other non-structural abnorma...

At birth, lung fluid clearance is coupled to Na+ transport through epithelial Na+ channels (ENaC) in the distal lung epithelium. We evaluated the effect of postnatal glucocorticoids (GC) on lung alpha-ENaC expression in preterm 29-day gestational age (GA) fetal rabbits. Postnatal treatment of 29-day GA fetuses with 0.5 mg/kg of dexamethasone (Dex) iv resulted in a 2- and 22-fold increase in lun...