Functional electrical stimulation (FES) is increasingly used by individuals with paralysis to regain functional movement, but muscle fatigue can limit the applicability of this technology. Mathematical predictions of power loss during electrically stimulated muscle contractions are essential when trying to not only minimize fatigue, but also determine the relative contributions of force and vel...

A new multiaxial high-cycle fatigue initiation life prediction model for railroad wheels is proposed in this paper. A general fatigue damage analysis methodology for complex mechanical components is developed and applied to the wheel/rail rolling contact fatigue problem. A 3-D elasto-plastic finite element model is used for stress analysis. A submodeling technique is used to achieve both comput...

A new model for fatigue damage evolution of polymer matrix composites is presented. The model is based on a combination of an orthotropic damage model and an isotropic fatigue evolution model. The orthotropic damage model is used to predict the orthotropic damage evolution within a single cycle. The isotropic fatigue model is used to predict the magnitude of fatigue damage accumulated as a func...

Abstract Introduction: Cancer is a major health issue in Iran and in the rest of the world. Fatigue is one of the most complex and the most prevalent cancer-related problems that can affect various aspects of life for cancer patients. It can cause numerous problems. Objective: The aim of this study was to determine the level of fatigue and its associated factors in patients with cance...

A recent two-parameter fatigue model, aimed at the prediction of the fatigue behaviour of composite materials, was applied to fatigue results available in the literature, concerning graphite/epoxy laminates subjected to tension-compression loadings. It was found that the model, successfully applied in the case of tension-tension and compression-compression fatigue, also works when the sign of s...

Titanium-alloy weldments have been extensively used in engineering structures, and accurate estimation of the fatigue life is beneficial for avoiding catastrophic failures in titanium-alloy structures. The weld pore is a common defect in these weldments that significantly influences the fatigue process. In this study, the weld-pore size and depth and its effect on the fatigue life of Ti-6Al-2Zr...

Muscle fatigue is a temporary decline in the force and power capacity of skeletal muscle resulting from muscle activity. Because control of muscle is realized at the level of the motor unit (MU), it seems important to consider the physiological properties of motor units when attempting to understand and predict muscle fatigue. Therefore, we developed a phenomenological model of motor unit fatig...

BACKGROUND Using phase 3 trial data for sunitinib versus interferon (IFN)-α in treatment-naive patients with metastatic renal cell carcinoma, retrospective analyses characterized sunitinib-associated fatigue and its impact on patient-reported health-related quality of life (HRQoL). METHODS Patients received sunitinib at a dose of 50 mg/day on a schedule of 4 weeks on/2 weeks off (375 patients...