نتایج جستجو برای: familial breast cancer
تعداد نتایج: 1032090 فیلتر نتایج به سال:
PURPOSE Genome-wide association studies have identified common genomic variants associated with increased susceptibility to breast cancer. In the general population, the risk associated with these known variants seems insufficient to inform clinical management. Their contribution to the development of familial breast cancer is less clear. PATIENTS AND METHODS We studied 1,143 women with breas...
OBJECTIVE To estimate the risk of malignant diseases in families of probands with the same mutation in the BRCA2 gene. DESIGN A cohort study using record linkage of a breast cancer family resource and the Icelandic Cancer Registry. SETTING Iceland. SUBJECTS Families of 995 breast cancer patients, from which 887 were tested for a single founder 999del5 mutation; 90 had the mutation and 797...
Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a fi...
Breast cancer is the most widespread cancer in women in western countries, currently accounting for one third of all cancers in women. 2 The lifetime risk of developing breast cancer is 9% in the United Kingdom, 10% in The Netherlands, and 12% in the United States. About 15%–20% of all cases of breast cancer are thought to be familial, 6 and about 5%–10% of all breast cancers are attributed to ...
BRCA1- and BRCA2-deficient cells display genomic instability due to impaired DNA repair and may subsequently be predisposed to malignant transformation. Cancers arising in BRCA1 gene mutation carriers differ substantially from sporadic breast cancers of age-matched controls in their histopathological appearance. BRCA1-related breast cancers have been morphologically associated with poorly diffe...
BACKGROUND Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. METHODS Clinica...
A mail questionnaire was distributed to residents of a retirement community as part of a study of factors associ ated with cancer risk in the elderly. Maternal and paternal age and birth order were not associated with increased risk. With the exception of a positive association between heart disease and prostate cancer, there was no association between a personal or familial history of allergy,...
Background & Objective : Nowadays breast cancer is one of the most causes of female mortality. Mammography is a valuable method for early detection of breast cancer. Mammographic sensitivity depends on some factors such as age, breast tissue density, menopausal status, systemic disease, familial history of breast cancer and others. This study was designed to compare the effects of two regimen...
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