Although uncommon, acquired hemophilia A (HA) is associated with a high rate of mortality due to severe bleeding. In spite of many hypotheses regarding the cause of acquired HA, there is as yet no established theory. In this study, we investigated the possibility that mutation(s) in the F8 gene may be correlated with the development of inhibitory autoantibodies. Direct sequencing analysis was p...

Abstract. The KASUMI block cipher and the confidentiality (f8) and integrity (f9) algorithms using KASUMI in feed back cipher modes have been standardized by the 3GPP. We designed compact and high-speed implementations and then compared several prototypes to existing designs in ASICs and FPGAs. Making good use of the nested structure of KASUMI, a lot of function blocks are shared and reused. Th...

The growth of aquaculture sector in Kenya has been anchored on farmed Nile tilapia Oreochromis niloticus. Different strains the species exist with unknown quality due to lack stock improvement programmes coupled by variations breeding and management practices different hatcheries. seeds supplied farmers have not exhibited good performance resilience changing climate. There is need validate fish...

The preparation and the properties of gold nanoparticles (Au NPs) protected by perfluorinated amphiphiles are described. The thiols were devised to form a perfluorinated region close to the gold surface and to have a hydrophilic portion in contact with the bulk solvent to impart solubility in water. The monolayer protected clusters were prepared, in an homogeneous phase using sodium thiolates b...

Phenotypic variability is well recognized in severe hemophilia A. A few studies, mainly in adults treated lifelong on demand, suggest that bleeding phenotype correlates with factor VIII gene (F8) mutation type. Because treatment regimens influence outcomes to a large extent, examining bleeding phenotype during the first years of life may be the most suitable way to define this variability. We s...

INTRODUCTION Hemophilia A is an X linked recessive hemorrhagic disorder caused by mutations in the F8 gene that lead to qualitative and/or quantitative deficiencies of coagulation factor VIII (FVIII). Molecular diagnosis of hemophilia A is challenging because of the high number of different causative mutations that are distributed throughout the large F8 gene. Molecular studies of these mutatio...

A simple matrix is a (0,1)-matrix with no repeated columns. For a (0,1)matrix F , we define that a (0,1)-matrix A has no F as a configuration if there is no submatrix of A which is a row and column permutation of F . Let |A| denote the number of columns of A. We define forb(m,F ) = max{|A| : A is an m-rowed simple matrix and with no configuration F}. For two matrices H,K we define [H |K] as the...

Hemophilia A is an X-linked bleeding disorder resulting mostly from heterogeneous point mutations in the factor VIII (F8) gene. Small/large gene deletions, insertions and gross gene rearrangements underlie the molecular pathogenesis of the disease. Two large inversion mutations due to intrachromosomal recombinations between inverted repeats found in intronic sequences and upstream regions of th...

The factor VIII gene (F8) intron 22 inversion (Inv22) is a paradigmatic duplicon-mediated rearrangement, found in about one half of patients with severe hemophilia A worldwide. The identification of this prevalent cause of hemophilia was delayed for nine years after the F8 characterization in 1984. The aim of this review is to present the wide diversity of practical approaches that have been de...