Due to the high complexity of some treatments, there is a need develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages treatment. In this study, thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within Pluronic hydrogel composed mixture F127 and F68. The increase in F68 ratio decrease lead hi...

Highly ordered three-dimensional Im3m-type periodic mesoporous organosilica with a cavity size of 9.8 nm has been synthesized under strongly acidic media in the presence of inorganic salts using triblock copolymer F127 as the template and 1,2-bis(trimethoxysilyl)ethane as the organically bridged silica source.

Mesoporous carbon nanomaterials have shown a great application potential in energy storage and conversion fields due to their outstanding conductivity, tunable pore structure, good chemical stability. Nevertheless, how accurately control the especially directly assembling mesoporous onto different substrates remains big challenge. Herein, we successfully assembled two kinds of highly nitrogen-d...

Our lab demonstrated that intratumoral Cowpea mosaic virus (CPMV) is a potent antitumor immunotherapy when used as in situ vaccine. As we pave the way for human clinical translation, formulation chemistry needs to be optimized long-term storage of drug candidate. In this work, CPMV was nanoengineered with Pluronic F127 realize liquid and gel formulations which mitigate structural changes RNA re...

Tiny nanoparticles of dexamethasone palmitate (DXP) were designed as transparent suspensions for intravitreal administration to treat age-related macular degeneration (AMD). The influence three surfactants (PEG-40-stearate and Pluronic block copolymers F68 F127) on size stability was investigated led an optimal formulation based F127 stabilizing DXP nanoparticles. Size measurements TEM revealed...

OBJECTIVE This study aims to test the hypothesis that targeted nanoparticle delivery of DNA encoding HPV16-regulated diphtheria toxin (DT-A) will result in the death of HPV16-infected cells. MATERIALS AND METHODS Plasmid constructs containing a HPV16 Long Control Region (LCR) DNA sequence upstream of DT-A or luciferase reporter (Luc) DNA sequences were used to formulate poly(β-amino ester) na...

BACKGROUND In the present study, synchrotron small-angle X-ray scattering (SAXS) and Cryo-TEM were used to characterize the temperature-induced structural transitions of monoelaidin (ME) aqueous dispersion in the presence of the polymeric stabilizer F127. We prove that the direct transition from vesicles to cubosomes by heating this dispersion is possible. The obtained results were compared wit...

The self-assembly of amphiphilic (porphyrin)Sn 1 in an aqueous Pluronic F127 media results in the formation of narrowly dispersed nanowires. Variation of aqueous Pluronic concentrations allows for a systematic variation of porphyrin nanowire lengths while keeping their widths constant. These nanowires can be further assembled into secondary macroscopic columns.

Multi-stimuli responsive hydrogels are synthesized using self-assembled nanomicelles of Pluronic F127 diacrylate triblock copolymer as non-covalent macro-crosslinkers to in situ copolymerize with acrylamide and methyl chloride quaternized N,N-dimethylamino ethylacrylate monomers, generating positively charged hydrogels. These hydrogels showed high strength, toughness, and outstanding fatigue re...

PURPOSE To develop an in situ gel system comprising liposome-containing paclitaxel (PTX) dispersed within the thermoreversible gel (Pluronic® F127 gel) for controlled release and improved antitumor drug efficiency. METHODS The dialysis membrane and membrane-less diffusion method were used to investigate the in vitro drug release behavior. Differential scanning calorimetry (DSC) thermal analys...