The orbit is a rare site for metastatic carcinoma (Duke-Elder, I952) and, although such orbital deposits may commonly involve muscle secondarily, discrete metastatic tumours in the extraocular muscles are extremely rare, as in muscle generally (Willis, I952, I953). A search of the literature has revealed four previous cases: two from carcinoma of the breast (Wintersteiner, I899; Bedford and Dan...

We have shown previously that the gain of the horizontal vestibulo-ocular reflex (HVOR) is modified by afferent signals from extraocular muscle proprioceptors in the decerebrate pigeon. We have now analysed the variability of the HVOR in intact, alert pigeons and, using the artificial vestibulo-ocular reflex method, have found that in all of the pigeons tested afferent signals from the extraocu...

As described in Chapter 4, the extraocular muscles perform two functions: optostatic and optokinetic. The optostatic function requires that the muscles maintain a state of postural tonicity; the optokinetic function requires that quick, tetanic contractions be performed. These two contradictory functions are served by two different sets of muscles in the skeletal muscle system. Eye muscles, how...

Introduction Many medical indications for orbital decompression exist in patients with Graves‘ orbitopathy (GO) of which the dysthyroid optic neuropathie (DON) is rather severe and has to be urgently treated. The neuropathy nerve commonly caused by swelling extraocular muscle tissue resulting a compression area apex orbitae or stretching proptosis. Most common symptoms include decreased color s...

AIM To assess levels of soluble Fas (sFas) in the sera of patients with Graves' ophthalmopathy. METHODS The subjects in this study were 43 patients with Graves' ophthalmopathy and 11 normal subjects. Serum levels of sFas were determined by sandwich enzyme linked immunosorbent assay. In addition, serum levels of thyroid stimulating antibody (TSAB) were also measured in all the patients. RESU...

The superior rectus muscle of the rabbit can be separated into two plates: One is comprised, solely of F elder struktur ("slow") fibers and the other almost exclusively of Fibrillenstruktur ("twitch") fibers. Responses of isolated portions of the two muscle types to acetylcholine were compared under identical experimental conditions. The results indicate that the Felderstruktur fibers are respo...

Extraocular muscle represents a distinctive class among mammalian skeletal musculature in exhibiting the full range of muscle fiber type variability found in vertebrate species. To better understand the basis for the unique structural/functional diversity of extraocular muscle, the ontogeny of lateral rectus muscles was studied in Macaca nemestrina fetuses of 62-156 days gestation using light a...

Kimura's disease (KD) is a rare, chronic inflammatory disorder, which is characterized by tumor-like masses mainly located in the head and neck region. Extraocular muscle involvement in KD is uncommon. We report a case of KD that involved both the extraocular muscles and buccal area. A 13-year-old male presented to our clinic with a two-year history of exophthalmos of the left eye and facial sw...

O phthalmologists are, and should be, proud of the advances in cataract surgery and aphakic correction that have occurred over the past two decades. Today, cataract surgery is considered one of the most successful surgical procedures performed throughout the world. The resulting quality of vision is usually excellent and the complication rate reasonably low. One postoperative complication, dipl...

PURPOSE Weak eye muscles can cause ophthalmic disorders, and in particular, strabismus. Exogenous trophic factors such as cardiotrophin (CT)-1 and insulin-like growth factor (IGF) have been shown to increase the contractile force of adult heart and skeletal muscles, respectively. In the current study, the effects of endogenous and exogenous trophic factors on extraocular muscle strength and mas...