Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femo...

OBJECTIVE The purpose of this paper is to investigate the fluid status of patients in the early stages of continuous ambulatory peritoneal dialysis (CAPD). PATIENTS AND METHODS A total of 36 patients (13 males and 23 females), hospitalized in the Nephrology CAPD Center, Peking University Third Hospital, and undergoing intubation and CAPD treatment, were recruited in this study. By utilize a b...

OBJECTIVE To present a practical approach to the management of osmolar disorders by considering the mechanisms involved in their development. DATA SOURCES Articles and published peer-review abstracts on the mechanisms and management of disorders of plasma osmolality. SUMMARY OF REVIEW In health, plasma osmolality is determined largely by the concentration of sodium and its accompanying anio...

Many medical and surgical emergencies are complicated by derangement of water and electrolyte balance, the successful management of which depends upon the rapid assessment of essential clinical and laboratory data, and the prompt institution of a certain pre-arranged routine of treatment. An attempt is made in this review to illustrate the application of physiological principles to specific cli...

From 8 to 15 mM of strong mineral acid per kilogram of body weight may be infused intravenously in the dog over a period of a few hours to produce a severe but non-fatal acidosis. Van Slyke and Cullen (1) showed that only one-sixth of the infused acid is neutralized by blood buffers, five-sixths presumably being neutralized by bicarbonate in interstitial fluid and lymph and by intracellular pho...

Reasonably satisfactory methods have been developed for estimation of plasma volume (1) and total body water (2, 3) in normal subjects. On the other hand, no entirely satisfactory substance for estimating the volume of the extracellular fluid has as yet been found. It is not surprising that the material for this purpose should be more difficult to select, since, in order to have a volume of dis...

The goal of these studies was to determine whether the hypertension caused by excessive salt loading results from sodium-induced expansion of the extracellular fluid volume or whether the salt increases the pressure in some other way, such as by causing vascular constriction. In one group of sheep, a combination of total nephrectomy and hemodialysis was used to produce and maintain step increas...

Administration of bupropion [(±)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one] and its preformed active metabolite, hydroxybupropion [(±)-1-(3-chlorophenyl)-2-[(1-hydroxy-2-methyl-2-propanyl)amino]-1-propanone], to rats with measurement of unbound concentrations by quantitative microdialysis sampling of plasma and brain extracellular fluid was used to develop a compartmental pharmacokinet...

AIM To investigate the relationship between serum albumin and extracellular fluid volume, as measured by multifrequency bioelectrical impedance, in stable patients treated by CAPD. METHOD Fifty-nine stable CAPD patients were assessed. Serum albumin (bromocresol green) and CRP, age, dialysate to plasma (D/P) creatinine ratio, normalized protein catabolic rate (nPCR), daily urine and peritoneal...

A study was designed to investigate the possibility that changes in ventral medullary extracellular fluid carbon dioxide tension (PCO2) and hydrogen ion (H+) concentration mediate the ventilatory stimulation induced by systemic administration of aminophylline. Six cats with peripheral chemodenervation (bilateral carotid sinus nerve and vagal neurotomy) were studied while anaesthetised with chlo...