The aim of this investigation was to test the hypothesis that extracellular guanosine regulates extracellular adenosine levels. Rat preglomerular vascular smooth muscle cells were incubated with adenosine, guanosine, or both. Guanosine (30 μmol/l) per se had little effect on extracellular adenosine levels. Extracellular adenosine levels 1 h after addition of adenosine (3 μmol/l) were 0.125 ± 0....

The cloning of a G protein-coupled extracellular Ca(2+) (Ca(o)(2+))-sensing receptor (CaR) has elucidated the molecular basis for many of the previously recognized effects of Ca(o)(2+) on tissues that maintain systemic Ca(o)(2+) homeostasis, especially parathyroid chief cells and several cells in the kidney. The availability of the cloned CaR enabled the development of DNA and antibody probes f...

six strain of trichoderma (t. viride, t. harzianum, t. reesei, t. longibrachiatum, t. koningii, t. virens) were isolated and used for extracellular enzyme production. species of trichoderma are collected from the surrounding soil of suger beet root fields in east iran, and held in vitro cultured pda. tcm and tfm are used for the growth of spores and induceing the production of cellulase. finall...

the objective of this study was to isolate halophilic bacteria with the ability to produce intracellular or extracellular l-asparaginase. a total number of 120 halophilic bacteria were isolated from 17 different saline habitats of iran including salt lakes, wetlands, brine springs and deserts. among these, 68 were able to grow in the presence of 1.5 m nacl and 52 demonstrated the ability to gro...

The morphology of retinal photoreceptor layer was studied in continuous light-exposed and dark-adapteddomestic male cats (Felis catus). The eyes of 12 healthy adult cats (4 in continuous light-exposed group, 4 in continuous dark-adapted group, and 4 in control group) were routinely fixed and studied by electron microscope. Results showed that the general structure of photoreceptor layer in this...

Glutamate is the most important excitatory neurotransmitter in the central nervous system which is involved in synaptic transmission, brain development, synaptic plasticity, learning, and memory. Normally, the enzymatic destruction of glutamate does not occur in the synaptic and extracellular space, but glutamate is removed through specific transporter proteins, leading to stabilization of glut...