A total of 72 mice were used for an experimental model of intestinal amoebiasis developed in the Swiss albino mice dividing into three groups, experimental immunocompetent mice group (Group-A), experimental immunodepressed mice group (Group-B) and control group (Group-C). The inoculum (10 cells of Entamoeba histolytica/0.2 ml of medium) was used to inoculate into the caecum of the experimental ...

Entamoeba histolytica, the protozoan responsible for human amoebiasis, causes between 30,000 and 100,000 deaths per year worldwide. Amoebiasis is characterized by intestinal epithelial damage provoking severe diarrhea. However, the molecular mechanisms by which this protozoan causes epithelial damage are poorly understood. Here, we studied the initial molecular interactions between the E. histo...

In 2011, the World Health Organization (WHO) determined that more than 700 million people were treated with at least one essential medicine for neglected tropical diseases (NTDs) under the auspices of a global preventive chemotherapy initiative [1,2]. However, a total of at least 1.9 billion people require annual preventive chemotherapy [1,2], so these efforts will need to be greatly expanded i...

Amoebiasis is a problem in northern India. In Ayurveda several herbal drugs are mentioned, to be used for controlling the amatisara (amoebiasis) but none of the drug are found having potent effect to iradicate the disease. In ancient literature kutaj (Holarrhena antidysentrica) is mentioned in commonest was for controlling the disease this plant is prevalently found in Himalayan and vindhaya ar...

The human protozoan parasite Entamoeba histolytica can live in the intestine for months or years without generating any symptoms host. For unknown reasons, amoebae suddenly destroy intestinal mucosa and become invasive. This lead to amoebic colitis extraintestinal amoebiasis whereby spread other organs via blood vessels, most commonly liver where abscesses develop. nuttalli is closest genetic r...