We describe a patient with a primary diffuse large B-cell lymphoma of the central nervous system who developed a localized testicular relapse after 8 years. Both tumours lacked HLA-DR expression, the relapse additionally lost HLA class I expression. Immunoglobulin heavy chain gene rearrangements were identical in both lymphomas with extensive and ongoing somatic hypermutations resulting in exte...

Certain tumours of the testis in man cause symptoms of a feminizing nature and arouse interest and comment out of all proportion to the frequency of their occurrence. Although these tumours are rare, the literature is extensive, as most of the cases tend to be reported, and their hormonal effects have been the subject of much conjecture and speculation. Despite all that has been written, this p...

the rectum villous tumour is an uncommon pathology in paediatrics, it represent 1% of all the children's malign tumours. an eleven-year-old girl present a rectal adenocarcinoma developed from a villous tumour. the aim of this study is to assess , an overview of litterature, the frequency of rectum villous tumours; to specify the value of the clinical examination , of the radiologic finding in t...

Third and fourth line chemotherapy agents are not helpful in the setting of extensive stage small cell lung cancer (SCLC). We describe the case of a 43-year-old Korean patient with T4N3M1b extensive stage SCLC who responded remarkably well to treatment and experienced a prolonged progression-free survival (PFS) period following treatment with fourth line ifosfamide and carboplatin after experie...

Background: Acoustic cavitation which occurs at high intensities of ultrasound waves can be fatal for tumor cells; however, it can be used to destroy cancer cells as an efficient therapeutic method. On the other hand, it is known that the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. Materials and Methods: In this work, the combined effects of therape...

Development and maintenance of tissue organization in complex organisms has long been suspected to involve altered cell surface interactions between adjacent cells. Similarly, the process of tumour metastasis undoubtedly requires the expression of appropriate attachment sites for the embedding and subsequent proliferation of secondary turnours. Exciting developments in molecular cell biology ar...

introduction: to report our experience with a large series of surgical procedures for removal of cerebellopontine angle (cpa) tumors using different approaches.   materials and methods: this was a retrospective analysis of 50 patients (mean age, 49 years) with cpa tumors (predominantly acoustic neuroma) who underwent surgical removal using appropriate techniques (principally a translabyrinthine...

Ten patients with ampullary carcinoma, not suitable for surgery, were treated with endoscopic photodynamic therapy (PDT) to evaluate the feasibility and safety of treatment. Patients received 4 mg kg-1 of haematoporphyrin derivative intravenously. Two days later, a duodenoscopy was performed and red (630 nm) light delivered to the tumour at fixed energy densities of 50 J or 200 J cm-1 per appli...

In the 7th edition of the TNM classification of malignant tumours some alterations and innovations for skin tumours were introduced including an entirely new classification for Merkel Cell Carcinomas. The changes are shown along with notes on some critical issues. The chapter “cutaneous squamous cell carcinoma and other cutaneous carcinomas” has been newly named and supplied with new definition...

Ovarian carcinomas exhibit extensive heterogeneity, and their etiology remains unknown. Histological and genetic evidence has led to the proposal that low grade ovarian serous carcinomas (LGOSC) have a different etiology than high grade carcinomas (HGOSC), arising from serous tumours of low malignant potential (LMP). Common regions of chromosome (chr) 3 loss have been observed in all types of s...