OBJECTIVE To evaluate the efficacy of curative and palliative radiotherapy in the treatment of extensive stage small cell lung cancer (E-SCLC), and compare therapy effect on survival with or without metastatic disease. METHODS From January 1998 through December 2004, 128 patients with E-SCLC were treated with radiotherapy and concomitants combined chemotherapy. Radical radiotherapy, consistin...

Modern Field-Programmable Gate Arrays (FPGAs) can accommodate complex system-on-chip designs and require extensive intellectual-property (IP) support. However, current IP protection mechanisms in FPGAs are limited, and do not reach beyond whole-design bit-stream encryption. This work presents an architecture and protocol for securing IP based designs in programmable platforms. The architecture ...

Using the concept of informational digraphs, we propose a “no redundant information sets” property that can characterize exact class extensive games which be time structured. Our result applied to define time-dependent solution concepts like Open-Loop and Closed-Loop Nash Equilibrium in with imperfect information.

The extent to which a place feels like a home is related in part to the physical condition of the property and its surrounding environment. Tenants and local authorities have been provided with extensive legal powers to force landlords to remedy defects since the late 19th century. Yet housing conditions within rented property remain poor. Problems relating to the boundaries of legal remedies w...

right of private property is of the most important individual rights of society that lies in the heart of private law. in islamic law protection of property as one of the five goals of fighhe, that is, protection of sagacity, religion, generation and self, is to be stipulated. based on article 140 of civil code the process of property acquisition is restricted to four cases. on the other hand, ...

riverbank erosion, land loss and associated sedimentation are river engineering and water resources management problems of global significance. the ability to predict riverbank stability on eroding rivers is the prerequisite of developing a channel width adjustment model and is essential for estimating riverbank erosion and associated sedimentation. in this research, a detailed model for stabil...

Small cell lung cancer (SCLC) is an aggressive disease, in which more than 80% of patients present distant metastases at the time of first diagnosis. Chemotherapy is considered as the main treatment of extensive disease of SCLC (ED-SCLC), while the role of radiotherapy in the treatment of ED-SCLC is controversial. A case-control study was undertaken of patients diagnosed as ED-SCLC between 2004...

Extensive stage small cell lung cancer (ES-SCLC) represents approximately half of all diagnosed small cell lung cancer worldwide. It is notorious for a high risk of local recurrence although it's sensitive to chemotherapy. Nearly 90% of intrathoracic failures happen in the first year after diagnosis. The cornerstone of treatment for ES-SCLC is etoposide-platinum based chemotherapy. Consolidativ...

OBJECTIVES Current National Comprehensive Cancer Network (NCCN) guidelines recommend thoracic consolidation radiation therapy (TCRT) for patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC) with response to systemic chemotherapy, based on two randomized clinical trials, which varied in patient selection and radiation therapy doses administered. The current pattern of practice among US...

PURPOSE The initial goal of this study was to test the immunologic and clinical effects of a new cancer vaccine consisting of dendritic cells (DC) transduced with the full-length wild-type p53 gene delivered via an adenoviral vector in patients with extensive stage small cell lung cancer. EXPERIMENTAL DESIGN Twenty-nine patients with extensive stage small cell lung cancer were vaccinated repe...