Large bone defects caused by trauma or disease needs extra intervention. Gelatin/chitosan complex is one of the most valuable compositions for healing, but fast degradation in aqueous solution and low mechanical properties increase need cross-linking agent. The cross-linker concentration method had a significant effect on fabricated scaffolds. Here, three different methods Glutaraldehyde (GA), ...

Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

in this research, aluminizing packs containing naf and nh4cl activators were used for aluminizing of pure titanium samples at 1100 ºc. the results showed that the layers of tial3, tial2, γ-tial, α2-ti3al, and α-solid solution are formed on titanium samples in both cases. however, the weight gain and the thickness of tial3 layer in treated samples with nh4cl activator are greater than those when...

Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with thes...

introduction: dna damage, as an important initiator of neuronal cell death, has been implicated in numerous neurodegenerative conditions. previously we have delineated several pathways that control embryonic cortical neuronal cell death evoked by the dna-damaging agent, camptothecin. the camptothecin, topoisomerase ι inhibitor, has been shown to induce cortical neuronal cell death in a reproduc...

Hypertonic solutions of different substances were injected into the vertebral artery of dogs anesthetized with chloralose, preventing their access to the hypothalamic osmoreceptors by ligating the basilar artery and both the external carotid arteries. The hypertonic solution of sodium chloride produced graded inhibition of water diuresis and a concomitant rise in plasma antidiuretic hormone (AD...

By using the penalty function method with objective parameters, the paper presents an interactive algorithm to solve the inequality constrained multi-objective programming (MP). The MP is transformed into a single objective optimal problem (SOOP) with inequality constrains; and it is proved that, under some conditions, an optimal solution to SOOP is a Pareto efficient solution to MP. Then, an i...