As a widely known hormone in animals, melatonin (N-acetyl-5-methoxytryptamine) has been more and more popular research topic in various aspects of plants. To summarize the these recent advances, this review focuses on the regulatory effects of melatonin in plant response to multiple abiotic stresses including salt, drought, cold, heat and oxidative stresses and biotic stress such as pathogen in...

BACKGROUND Patients with nocturnal hypertension are at higher risk for cardiovascular complications such as myocardial infarction and cerebrovascular insult. Published studies inconsistently reported decreases in nocturnal blood pressure with melatonin. METHODS A meta-analysis of the efficacy and safety of exogenous melatonin in ameliorating nocturnal blood pressure was performed using a rand...

PURPOSE With the wide recognition of oncostatic effect of melatonin, the current study proposes a potential breast cancer target multimodality treatment based on melatonin-loaded magnetic nanocomposite particles (Melatonin-MNPs). METHODS Melatonin-MNPs were fabricated by the single emulsion solvent extraction/evaporation method. RESULTS Based on the facilitated transport of melatonin by the...

Melatonin is an important secondary messenger in plant innate immunity against the bacterial pathogen Pseudomonas syringe pv. tomato (Pst) DC3000 in the salicylic acid (SA)- and nitric oxide (NO)-dependent pathway. However, the metabolic homeostasis in melatonin-mediated innate immunity is unknown. In this study, comparative metabolomic analysis found that the endogenous levels of both soluble ...

Context: Melatonin is a hormone synthesized principally in the pineal gland that has been classically associated with endocrine actions. Exogenous melatonin often used to treat insomnia and enhance sleep quality range of situations, including jet lag. However, benefit safety profile daytime dosing prior exercise are unknown warrant additional exploration. Objectives: We aimed give (i) brief ove...

Urine was collected from rats during 12 consecutive daily dark periods and assayed for melatonin and norepinephrine; the phase of the vaginal estrous cycle associated with each urine sample was determined from daily vaginal smears. The proestrous phase of the estrous cycle was consistently associated with significant reductions in the excretions of both compounds. The level of melatonin in any ...

Background: Although chemotherapy drugs used in treatment of cancer such as lukemia, prostate and ovary cancer and oligospermia is important contraceptive of this drugs therefore this drugs are author of infertility or low fertility in specimen. In the other hand, the studies show that melatonin is secreted from pineal gland has a direct efficacy on the gonads. The aim of this study was to inve...

Melatonin is an indoleamine with multiple functions in both plant and animal species. In addition to data in literature describing many other important roles for melatonin, such as antioxidant, circadian rhythm controlling, anti-aging, antiproliferative or immunomodulatory activities, our group recently reported that thyroid C-cells synthesize melatonin and suggested a paracrine role for this m...

Melatonin is a pineal hormone produced at night; however, many strains of laboratory mice are deficient in melatonin. Strangely enough, the gene encoding HIOMT enzyme (also known as ASMT) that catalyzes the last step of melatonin synthesis is still unidentified in the house mouse (Mus musculus) despite the completion of the genome sequence. Here we report the identification of the mouse Hiomt g...

Mexican lime is one of the commercial citrus cultivars in the world, which is commonly used as a citrus rootstock in the southern regions of Iran. This cultivar is one of the most sensitive citrus cultivars to cold stress and is used as a cold-sensitive plant in many citrus studies. This study aimed to investigate the effect of melatonin (0 and 500 μM), mannitol (0 and 50 μM), acetic acid (0 an...