The effect of a number of antibiotics on stop codon readthrough during protein synthesis in Escherichia coli was examined. Inhibitors which bind close to the entrance of the peptide exit tunnel on the 50S ribosomal subunit promote substantial levels of readthrough, presumably by disrupting the mechanism of peptide release.

A topological existence proof is presented for certain symmetrical periodic orbits of the collinear three-body problem with two equal masses, called Schubart orbits. The proof is based on the construction of a Wazewski setW in the phase space. The periodic orbits are found by a shooting argument in which symmetrical initial conditions enteringW are followed under the flow until they exit W. Top...

Introduction: Delivering maximum dose to tumor and minimum dose to normal tissues is the most important goal in radiotherapy. According to ICRU, the maximum acceptable uncertainty in the delivered dose compared to the prescribed dose should be lower than 5%, and this is because of the relationship between absorbed dose, tumor control and normal tissue damage. Absorbed dose accuracy is investiga...

Bacteria such as Escherichia coli and Pseudomonas aeruginosa expel antibiotics and other inhibitors via tripartite multidrug efflux pumps spanning the inner and outer membranes and the intervening periplasmic space. A key event in pump assembly is the recruitment of an outer membrane-anchored TolC exit duct by the adaptor protein of a cognate inner membrane translocase, establishing a contiguou...

In this paper, we construct various special solutions on a convergent-divergent surface for the steady compressible complete Euler system and established the stability of the purely subsonic flows. For a given pressure p0 prescribed at the “entry” of the surface, as the pressure p1 at the “exit” decreases, the flow patterns on the surface change continuously as those happen in a de Laval nozzle...

One of the more challenging aspects of hybrid permanent magnet undulator design is end-field termination. Klaus Halbach provided indication of correct excitation patterns for tapered wigglers, but implementation on hybrid undulators has proven more difficult. Initial results on APS undulators achieved complete passive gap dependence of both total residual angle and trajectory through the device...

RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exi...

A topological existence proof is given for a figure-eight periodic solution of the equal mass three-body problem. The proof is based on the construction of a Wazewski set W in the phase space. The figure-eight solution is then found by a kind of shooting argument in which symmetrical initial conditions entering W are followed under the flow until they exit W . A linking argument shows that the ...

There are not many known ways to break Tor anonymity, and they require an enormous amount of computational power. Controlling both entrance and exit nodes allows an attacker to compromise client IP with enough pattern analysis. If an .onion or public website does not use SSL, information will not be encrypted once it reaches the exit node. Tor has been successfully broken by Carnegie Mellon, ho...