Cells operate a signaling network termed the unfolded protein response (UPR) to monitor protein-folding capacity in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. Convergent...

knowing of formation of a legal rule is an efficient way to recognizing and assessing of that rule. anticipatory breach doctrine became apparent in common law when the court in hochster versus de la tour case (1980), hold that a party could breach an executor contract prior to the performance date and injured party entitle to sue at once. before it, courts had made a negative answer to this mat...

A loop with irregular assignment computations contains loopcarried output data dependences that can only be detected at run-time. In this paper, a load-balanced method based on the inspector-executor model is proposed to parallelize this loop pattern. The basic idea lies in splitting the iteration space of the sequential loop into sets of conflictfree iterations that can be executed concurrentl...

Apps on Google’s Android mobile device platform are written in Java, but are compiled to a special bytecode language called Dalvik. In this paper, we introduce SymDroid, a symbolic executor that operates directly on Dalvik bytecode. SymDroid begins by first translating Dalvik into μ-Dalvik, a simpler language that has only 16 instructions, in contrast to Dalvik’s more than 200 instructions. We ...

Graph partitioners play an important role in many parallel work distribution and locality optimization approaches. Surprisingly, however, to our knowledge there is no freely available parallel graph partitioner designed for execution on a shared memory multicore system. This paper presents a shared memory parallel graph partitioner, ParCubed, for use in the context of sparse tiling run-time dat...

The elasticity feature of cloud computing and its pay-per-use pricing entice application providers to use cloud application hosting. One of the most valuable methods, an application provider can use in order to reduce costs is resource auto-scaling. Resource autoscaling for the purpose of preventing resource over-provisioning or under-provisioning is a widely investigated topic in cloud environ...

This paper discusses a novel approach to implementing OpenMP on clusters. Traditional approaches to do so rely on Software Distributed Shared Memory systems to handle shared data. We discuss these and then introduce an alternative approach that translates OpenMP to Global Arrays (GA), explaining the basic strategy. GA requires a data distribution. We do not expect the user to supply this; rathe...

We present LocationSpark, a spatial data processing system built on top of Apache Spark, a widely used distributed data processing system. LocationSpark offers a rich set of spatial query operators, e.g., range search, kNN, spatio-textual operation, spatial-join, and kNN-join. To achieve high performance, LocationSpark employs various spatial indexes for in-memory data, and guarantees that immu...

ÐThis paper presents a time stamp algorithm for runtime parallelization of general DOACROSS loops that have indirect access patterns. The algorithm follows the INSPECTOR/EXECUTOR scheme and exploits parallelism at a fine-grained memory reference level. It features a parallel inspector and improves upon previous algorithms of the same generality by exploiting parallelism among consecutive reads ...