Ten patients with sickle cell anemia underwent partial exchange transfusion with hemoglobin-A-containing cells using a technique that allowed hemoglobin concentration and blood volume to remain constant. The mean fraction of hemoglobin-A in these patients increased from 9% to 55%, but the mean hemoglobin concentration increased by only 1.44 g/dl. The exchange resulted in a large improvement in ...

Intruduction: There is a growing concern about an increasing bilirubin-induced neurological dysfunction (BIND) in healthy term neonates with no evidence of hemolytic disease or other risk factors. This study was done to determine the incidence of BIND in otherwise healthy, breast-fed newborn term infants without hemolysis who underwent exchange transfusion.   Methods: This study was conducted i...

It is still not clear whether jaundice of unknown aetiology, developing during the neonatal period, is of significance for the subsequent development of athetosis and related diseases. In a previous study (Trolle, 1961), the author calculated that among children who have had neonatal jaundice of unknown aetiology, athetosis of later onset is so uncommon that the decision to perform an exchange ...

The first recorded case of recovery from hepatic coma after an exchange blood transfusion was that of Lee and Tink (1958). They gave two exchange transfusions of fresh blood to a boy aged 13 who was deeply jaundiced and comatose. After the first transfusion of 3,260 ml. his condition was unchanged, but when a second exchange of 3,140 ml. was given he improved and recovered completely. Trey et a...