Leishmaniasis is a neglected tropical disease that requires timely and inexpensive treatment. For this purpose, nanoemulsion with polyene macrolide antibiotic, or amphotericin B (NE-AmB), was developed. This study quantified the amount of drug permeated retained in intact lacerated human skin, simulating cutaneous leishmaniasis (CL) processes. Toxicity macrophage keratinocyte cell lines, activi...

Purpose To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined fo...

dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. the aim of this study is to develop ocular dorzolamide hcl nanoliposomes (drz – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. nanoliposomes were prepared using reverse-phase evaporation vesicle (rev) and thin layer hydration (tlh...

Gold nanoparticles (AuNPs) have great potential as carriers for local drug delivery and as a primary therapeutic for treatment of inflammation. Here we report on the AuNP-synovium interaction in an ex vivo model of intra-articular application for treatment of joint inflammation. Sheets of porcine femoropatellar synovium were obtained post mortem and each side of the tissue samples was maintaine...

The objective of the present study was to formulate and evaluate a thermoreversible formulation containing rizatriptan benzoate for intranasal administration. Chitosan and aqueous β−glycerolphosphate were mixed in cold condition to obtain chitosan-β−glycerolphosphate mixtures, which served as the thermoreversible systems. Rizatriptan benzoate was incorporated at a fi nal strength of 25 mg/ml. B...

The aim of the present study was to investigate the potential of Transfersomal gel formulations for transdermal delivery of Celecoxib and to evaluate the effect of concentration of Soya PC and Sodium deoxycholate. Transfersomal vesicles containing Soya PC mixed with Sodium deoxycholate and Celecoxib were prepared by conventional rotatory evaporation (Film hydration method) and characterized for...

The available minoxidil formulations for topical application suffer with major drawback and requires repeated application. The present study was aimed to investigate the effect of microemulsions and microemulsion based hydrogel-systems (MEHs) for increased percutaneous penetration of minoxidil. Minoxidil microemulsions were developed by conventional titration method using oleic-acid as oil, twe...

the introduction of ex vivo lung perfusion (evlp) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. in addition, evlp can provide a platform for the application of various preventive measures to decrease the incidence of post-transplant complications. while the toronto team targets the attenuation of th...

Ondansetron hydrochloride, a 5 HT3 antagonist is a powerful antiemetic drug which has oral bioavailability of 60% due to hepatic first pass metabolism and has a short half-life of 5 h. To overcome the above draw back, the present study was carried out to formulate and evaluate fast dissolving films of ondansetron hydrochloride for sublingual administration. The films were prepared from polymers...

The advancement of the biological production of nanoparticles using herbal extracts performs a significant role in nanotechnology discipline as it is green and does not engage harsh chemicals. The objective of the present investigation was to extract flavonoids in the mode of apple extract and synthesize its silver nanoparticles and ultimately nanoparticles loading into hydrogels. The presence ...