نتایج جستجو برای: ewing

تعداد نتایج: 2735  

2017
Colin Moore Janet K Parrish Paul Jedlicka

Ewing Sarcoma is an aggressive, oncofusion-driven, malignant neoplasm of bone and soft tissue affecting predominantly children and young adults. Seeking to identify potential novel therapeutic targets/agents for this disease, our previous studies uncovered microRNAs regulated by EWS/Fli1, the most common oncofusion, with growth modulatory properties. In the present study, we sought to identify ...

2016
Monika Twardziok Susann Kleinsimon Jana Rolff Sebastian Jäger Angelika Eggert Georg Seifert Catharina I. Delebinski

Ewing sarcoma is the second most common bone cancer in children and adolescents, with poor prognosis and outcome in ~70% of initial diagnoses and 10-15% of relapses. Hydrophobic triterpene acids and hydrophilic lectins and viscotoxins from European mistletoe (Viscum album L.) demonstrate anticancer properties, but have not yet been investigated for Ewing sarcoma. Commercial Viscum album L. extr...

Journal: :Science Advances 2021

A miRNA-based in vivo reporter deciphers cell heterogeneity Ewing sarcoma.

2014
Allison F. O'Neill Jason L.J. Dearling Yuchuan Wang Tanya Tupper Yanping Sun Jon C. Aster Monica L. Calicchio Antonio R. Perez-Atayde Alan B. Packard Andrew L. Kung

Purpose: Ewing sarcoma is a tumor of the bone and soft tissue characterized by diffuse cell membrane expression of CD99 (MIC2). Single-site, surgically resectable disease is associated with an excellent 5-year event-free survival; conversely, patientswith distantmetastases have a poor prognosis.Noninvasive imaging is the standard approach to identifying sites of metastatic disease. We sought to...

2013
Michael J. Monument Nicholas M. Bernthal R. Lor Randall

Despite a heightened appreciation of the many defining molecular aberrations in Ewing sarcoma, the cooperative genetic environment and permissive cell of origin essential for EWS/ETS-mediated oncogenesis remain elusive. Consequently, inducible animal and in vitro models of Ewing sarcoma from a native cellular context are unable to fully recapitulate malignant transformation. Despite these short...

2012
Giusy Di Conza Marianna Buttarelli Olimpia Monti Marsha Pellegrino Francesca Mancini Alfredo Pontecorvi Katia Scotlandi Fabiola Moretti

Ewing sarcoma is one of themost frequent bone cancers in adolescence. Althoughmultidisciplinary therapy has improved the survival rate for localized tumors, a critical step is the development of new drugs to improve the long-term outcome of recurrent and metastatic disease and to reduce side effects of conventional therapy. Here, we show that the small molecule reactivation of p53 and induction...

Journal: :Oncology reports 2014
Michel Pinheiro Dos Santos Caroline Brunetto de Farias Rafael Roesler Algemir Lunardi Brunetto Ana Lucia Abujamra

Histone deacetylase inhibitors and bisphosphonates have a promising future in the treatment of cancer as targeted anticancer drugs, particularly when used together or in combination with other cytotoxic agents. However, the effects of these combined treatments have not yet been systematically evaluated in Ewing sarcoma. The in vitro effects on cellular proliferation, viability and survival were...

Journal: :Molecular cancer therapeutics 2012
Giusy Di Conza Marianna Buttarelli Olimpia Monti Marsha Pellegrino Francesca Mancini Alfredo Pontecorvi Katia Scotlandi Fabiola Moretti

Ewing sarcoma is one of the most frequent bone cancers in adolescence. Although multidisciplinary therapy has improved the survival rate for localized tumors, a critical step is the development of new drugs to improve the long-term outcome of recurrent and metastatic disease and to reduce side effects of conventional therapy. Here, we show that the small molecule reactivation of p53 and inducti...

2014
Jozef Ban Dave N.T. Aryee Argyro Fourtouna Wietske van der Ent Max Kauer Stephan Niedan Isidro Machado Carlos Rodriguez-Galindo Oscar M. Tirado Raphaela Schwentner Piero Picci Adrienne M. Flanagan Verena Berg Sandra J. Strauss Katia Scotlandi Elizabeth R. Lawlor Ewa Snaar-Jagalska Antonio Llombart-Bosch Heinrich Kovar

The developmental receptor NOTCH plays an important role in various human cancers as a consequence of oncogenic mutations. Here we describe a novel mechanism of NOTCH-induced tumor suppression involving modulation of the deacetylase SIRT1, providing a rationale for the use of SIRT1 inhibitors to treat cancers where this mechanism is inactivated because of SIRT1 overexpression. In Ewing sarcoma ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Jennifer Town Helio Pais Sally Harrison Lucy F Stead Carole Bataille Wilawan Bunjobpol Jing Zhang Terence H Rabbitts

The cell surface proteome of tumors mediates the interface between the transformed cells and the general microenvironment, including interactions with stromal cells in the tumor niche and immune cells such as T cells. In addition, the cell surface proteome of individual cancers defines biomarkers for that tumor type and potential proteins that can be the target of antibody-mediated therapy. We ...

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