For more than 3 decades it has been known that serum thyroid hormone levels drop during starvation and illness. In mild illness, this involves only a decrease in serum T3 levels. However, as the severity of the illness increases, there is a drop in both serum T3 and T4 (1). This decrease in serum thyroid hormone levels is seen in starvation (2), sepsis (3, 4), surgery (5), myocardial infarction...

Chronic renal failure (CRF) patients on prolonged dialysis have been found to have significant alteration in their thyroid status, but little is known about the same in undialyzed CRF patients. Oxidative stress has been implicated as the key player in altering the levels of thyroid hormone in euthyroid sick syndrome. This study was performed to evaluate the levels of oxidative stress and thyroi...

We report an anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia (elevated free thyroxine, fT4 and normal 3, 5, 3'-L-triiodothyronine, T3) and suspected impairment of conversion from T4 to T3. Despite marked hyperthyroxinemia, this patient's perioperative hemodynamic profile was suspected to be the result of hypothyroidism, in reference to the presence of T4 to T3 con...

This is a procedure for rapidly identifying the three common abnormalities in binding of thyroxin by protein. After incubation with [125I]thyroxin, serum proteins are separated by electrophoresis on agarose gel and binding of thyroxin to the various protein fractions is determined after autoradiography. Quantitatively abnormal binding to albumin or prealbumin and thyroxin autoantibodies is easi...

We used various kits to measure free thyroxin (T4) in serum from a patient with the very rare syndrome of euthyroid hyperthyroxinemia secondary to increased thyroxin-binding prealbumin in serum. This patient's free T4 by equilibrium dialysis was 13 ng/L (normal 9-21), whereas the free-T4 index was 18.6 (normal 5.5-11.5). Using six different commercial methods, the last three listed being T4-ana...

CLINICALCHEMISTRY, Vol. 34, No. 3, 1988 599 2. Stockigt JR, De Garis M, Barlow JW. “Unbound analog” methods for free T4: a note of caution. N Engi J Med 1982;307:126. 3. De Nayer P, Malvaux P, Beckers C. Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the “analog” methods for assaying free T4 levels. Eur J Nuci Med 1984;9:284-5. 4. Stockigt JR, Dyer SA, Mohr VS. White EL, BarlowJ...

AIMS To estimate harmful alcohol habits in a sample of incident sick-listed individuals compared with a random sample from the general population taking social background, health and work-related factors into account. METHODS Data for this cross-sectional questionnaire study were collected in 2008 in the Västra Götaland region, Sweden. The study population (19-64 year olds) consisted of 2888 ...